高原地区高血压患者红细胞指标和血清高迁移率族蛋白2与颈动脉粥样硬化的相关性  

Relationship between Indexes of Red Blood Cells and Serum High Mobility Group Protein Box-2 and Carotid Atherosclerosis in Hypertension Patients from Plateau Area

作　　者：李方安[1] 汤晓丹 蔡波[1] 万进东 郭文超 孙垒 王沛坚[2,3] LI Fang-an;TANG Xiao-dan;CAI Bo;WAN Jin-dong;GUO Wen-chao;SUN Lei;WANG Pei-jian(Department of Cardiology,The People' Hospital of Aba Prefecture of Sichuan Province,Maerkang,Sichuan,624000,China;Department of Cardiology,The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan,610500,China;Key Laboratory of Aging and Vascular Homeostasis,Sichuan Provincial Universities,Chengdu,Sichuan,610500,China)

机构地区：[1]阿坝州人民医院心血管内科,四川马尔康624000 [2]成都医学院第一附属医院心血管内科,四川成都610500 [3]衰老与血管稳态四川省高校重点实验室,四川成都610500

出　　处：《现代生物医学进展》2019年第12期2316-2319,2303,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81400289);四川省杰出青年学术技术带头人资助计划(2016JQ0032);四川省教育厅科研创新团队项目(18TD0030);四川省医学会科研项目(S15022);成都医学院科研创新团队项目(CYTD16-01)

摘　　要：目的:探讨高原地区高血压患者红细胞指标和血清高迁移率族蛋白2(HMGB2)与颈动脉粥样硬化的相关性。方法:本研究共纳入244例高原地区高血压患者,通过检测颈动脉内膜中层厚度(IMT)分三组:内膜正常组(0.8 mm≤IMT<1.0 mm);内膜增厚组(1.0 mm≤IMT<1.2 mm);斑块形成组(IMT≥1.2 mm)。收集患者的临床资料,检测患者红细胞指标和血清HMGB2水平及其他生化指标。通过分析IMT与各项指标之间的相关性,评价颈动脉硬化的相关因素。结果:三组间红细胞压积(HCT)、红细胞计数(RBC)、红细胞分布宽度(RDW)、血清HMGB2水平差异均具有统计学意义(均P<0.05)。相关分析结果显示,RBC(r=0.368)、HCT(r=0.409)、RDW(r=0.596)、HMGB2(r=0.291)与IMT呈正相关(均P<0.05)。多因素Logistic回归分析显示RBC、HCT、RDW、HMGB2是颈动脉硬化的独立危险因素。结论:高原地区高血压患者RBC、HCT、RDW、HMGB2水平与IMT密切相关,且RBC、HCT、RDW、HMGB2水平升高是颈动脉硬化发生的危险因素,可作为动脉硬化早期预测因子。Objective: To investigate the relationship between indexes of red blood cells and serum high mobility group box-2(HMGB2) and carotid atherosclerosis in hypertension patients from plateau area. Methods: 224 hypertensive patients from plateau area underwent carotid ultrasonography, and were divided into three groups according to the carotid intima-media thickness(IMT), normal intima group(0.8 mm ≤ IMT< 1.0 mm), intimal thickening group(1.0 mm ≤IMT<1.2 mm), plaque formation group(IMT≥1.2 mm).Clinical data, indexes of erythrocyte, serum HMGB2 levels, and biochemical indexes were examined.Correlation between each index and IMT were analyzed, and the risk factors influencing the formation of carotid atherosclerosis plaque were analyzed by logistic regression. Results: The levels of red blood cell(RBC) count, hematocrit(HCT), red blood cell distribution width(RDW), and HMGB2 in three groups were significantly different from each other(P<0.05, respectively). Results of correlation analysis showed the correlation of RBC level(r=0.368), HCT level(r=0.409), RDW level(r=0.596), HMGB2 level(r=0.291) and IMT were positive(P<0.05, respectively). Multivariate logistic regression analysis indicated that RBC, HCT, RDW, and serum HMGB2 were independent risk factors for carotid atherosclerosis plaque formation(P<0.05, respectively). Conclusions: Elevated levels of RBC, HCT, RDW, serum HMGB2 have intimate connection with IMT, and have practical value in estimating the early atherosclerosis of hypertension patients from plateau area.

关 键 词：高原 高迁移率族蛋白2 颈动脉内膜-中层厚度 高血压 红细胞 

分 类 号：R135.6[医药卫生—劳动卫生] R543.5[医药卫生—公共卫生与预防医学]