维生素A、D治疗毛细支气管炎和儿童支气管哮喘的临床效果研究  

Curative Efficacy of Vitamins A and D in the Treatment of Bronchiolitis and Childhood Bronchial Asthma

作　　者：王安丽[1] 李丽[2] 王媛媛[1] 冯子鉴[2] 蒋华芳[3] WANG An-li;LI Li;WANG Yuan-yuan;FENG Zi-jian;JIANG Hua-fang(Department of Pediatric,Weifang Maternal and Child Health Hospital,Weifang,Shandong,261011,China;Department of Pediatric,Weifang Maternal and Child Health Hospital,Weifang,Shandong,261011,China;Department of Neonatology,Weifang Maternal and Child Health Hospital,Weifang,Shandong,261011,China)

机构地区：[1]潍坊市妇幼保健院儿二科,山东潍坊261011 [2]潍坊市妇幼保健院儿三科,山东潍坊261011 [3]潍坊市妇幼保健院新生儿科,山东潍坊261011

出　　处：《现代生物医学进展》2019年第12期2366-2369,共4页Progress in Modern Biomedicine

基　　金：山东省自然科学基金项目(ZR2016HL44)

摘　　要：目的:探讨维生素A、D治疗毛细支气管炎和儿童支气管哮喘的临床效果。方法:选取2016年1月-2018年1月本院住院治疗的毛细支气管炎患儿120例、门诊就诊的支气管哮喘患儿120例、儿童保健门诊查体的健康患儿40例(近1年均无服用维生素AD史)作为研究对象。将毛细支气管炎组、哮喘组分别随机分为治疗组40例(常规治疗+口服维生素AD组)和对照组40例(常规治疗组)。治疗组补充口服维生素AD1粒qd,疗程共6个月。分别比较三组血清维生素A、D水平,随访6个月、1年内喘息的控制情况(喘息发作次数、持续时间、咳嗽程度、有无夜间症状或夜间憋醒、有无活动受限)及肺功能(第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC),哮喘组≥4岁患儿进行儿童哮喘控制测试(C-ACT)评分评价哮喘的控制情况。结果:观察组与对照组患儿血清维生素A、D水平无显著性差异(P>0.05);观察组、对照组患者维生素A、D水平显著低于健康组患儿(P<0.05);观察组患儿喘息发作次数、喘息发作时间、夜间症状、夜间憋醒、活动受限发生情况均显著低于对照组(P<0.05)。治疗后,两组各肺功能指标较治疗前均显著升高(P<0.05),观察组FEV1、FVC、FEV1/FVC水平及C-ACT评分均明显高于对照组(P<0.05),观察组进展支气管哮喘的发生率明显低于对照组(P<0.05)。结论:维生素A、D治疗毛细支气管炎和儿童支气管哮喘的临床效果显著。Objective: To study Curative efficacy of Vitamins A and D in treatment of Bronchiolitis and childhood bronchial asthma.Methods: 120 cases of children with bronchiolitis admitted to our hospital from January 2016 to January 2018, 120 cases of children with bronchial asthma admitted to our outpatient department, and 40 cases of healthy children(no history of taking vitamin AD for nearly a year) examined in the outpatient department of children’s health care were selected as subjects, the bronchiolitis group and asthma group were randomly divided into treatment group(40 cases) and control group(40 cases). The treatment group received oral vitamin AD1 qd supplement for 6 months. Respectively to compare three groups of serum vitamin A, D levels were followed up for 6 months, 1 year of control of breathing(breathing attack frequency, duration, and degree of cough, with or without symptoms or suppress wake up at night by night, and presence of restricted movement), and the evaluation of the lung function status(forced expiratory volume in 1 second(FEV1) and forced vital capacity(FVC), FEV1/FVC);In the asthma group, children aged 4 years old were assessed for asthma control by c-act score. Results: There was no significant difference in vitamin A and D levels between the observation group and the control group(P>0.05). The levels of vitamin A and D in the observation group and the control group were significantly lower than those in the healthy group(P<0.05). The number and duration of attack were significantly lower in the observation group than in the control group(P<0.05). The incidence of nocturnal symptoms, nocturnal anapnea and activity restriction in the observation group was significantly lower than that in the control group(P<0.05). Before treatment, there was no significant difference in pulmonary function between the two groups(P>0.05). After treatment, lung function indexes in both groups were significantly higher than before treatment(P<0.05), and FEV1, FVC and FEV1/FVC levels in the observation group were

关 键 词：维生素A 维生素D 毛细支气管炎 支气管哮喘 

分 类 号：R563.12[医药卫生—呼吸系统] R562.25[医药卫生—内科学]