近红外光谱技术在新生儿坏死性小肠结肠炎肠道血氧饱和度测定中的研究  

Near-Infrared spectroscopy in the measurement of intestinal blood oxygen saturation in neonatal necrotizing enterocolitis

作　　者：毛建雄[1] 肖东[1] 张翅[1] 邢大军[2] 王秀良 王智勇[1] 任锋[1] 陈刚 崔雄俭 张平[3] MAO Jian-xiong;XIAO Dong;ZHANG Chi;XING Da-jun;WANG Xiu-liang;WANG Zhi-yong;REN Feng;CHEN Gang;CUI Xiong-jian;ZHANG Ping(Shenzhen Children's Hospital,General Surgery Department,Shenzhen 518038;Shenzhen Children's Hospital,Anesthesiology Department,Shenzhen 518038;Shenzhen Children's Hospital,Operating Room,Shenzhen 518038)

机构地区：[1]深圳市儿童医院普外一科,深圳518038 [2]深圳市儿童医院麻醉科,深圳518038 [3]深圳市儿童医院手术室,深圳518038

出　　处：《中国优生与遗传杂志》2019年第7期841-843,893,共4页Chinese Journal of Birth Health & Heredity

基　　金：深圳市科技计划项目,编号:JCYJ20170303160036705

摘　　要：目的通过近红外光谱技术测定新生儿坏死性小肠结肠炎肠管血氧饱和度,以及肠管血氧饱和度在发病过程中的变化趋势。方法选取非肠道疾病新生儿30例作为对照组,确诊坏死性小肠结肠炎并保守治疗成功新生儿30例。通过近红外光谱仪(脑血氧饱和度仪)分别测定上腹部,下腹部,左侧腹,右侧腹四个部位肠道血氧饱和度值,每天测定两次,取平均值,连续测定7天。收集数据后进行统计分析。组内同一测量部位不同天数之间对比采用方差分析,组间同一部位不同天数之间的对比采用t检验。结果对照组同一测量部位不同天数之间,P>0.05,无统计学意义,实验组内同一测量部位,不同天数之间,P<0.05,有显著统计学差异。对照组与实验组之间同一部位不同天数之间,P<0.05,有显著统计学差异。结论近红外光谱技术是测量肠管血氧饱和度的有效方法,通过所测的血氧饱和度值来判断肠管的血液循环,对于新生儿坏死性小肠结肠炎的诊断以及疾病发展趋势的判断有一定意义。Objective:To determine the intestinal oxygen saturation in neonates with necrotizing enterocolitis by near infrared spectroscopy(NIRS),and the trend of intestinal oxygen saturation in the course of neonatal necrotizing enterocolitis. Methods:Thirty neonates with non-intestinal diseases were selected as control group. Thirty neonates with necrotizing enterocolitis were diagnosed and successfully treated conservatively. The intestinal oxygen saturation of the upper abdomen,the lower abdomen,the left abdomen and the right abdomen were measured by near infrared spectroscopy,once a day for 7 consecutive days. Data were collected and analyzed. Variance analysis was used to compare the different days of the same measurement site in the same group,and t test was used to compare the different days of the same location in the same group. Result:There was no significant difference between different days at the same measuring site in the control group(P>0.05). There was significant difference between the same measuring site and different days in the experimental group(P<0.05). There was significant difference between the control group and the experimental group in different days at the same site(P<0.05). Conclusion:Near infrared spectroscopy is an effective method to measure intestinal oxygen saturation. The blood circulation of intestinal canal can be judged by the measured oxygen saturation. It has certain significance for the diagnosis of neonatal necrotizing enterocolitis and the judgment of disease development trend.

关 键 词：坏死性小肠结肠炎 NEC 近红外光谱 肠道血氧饱和度 

分 类 号：R722.1[医药卫生—儿科]