岩藻聚糖硫酸酯FV对大鼠的抗血栓作用研究  

Antithrombotic effect of fucoidan from fucus vesiculosus FV on rats

作　　者：闫晨[1] 邸志权[2] 朱振娜[2] 霍璇[2] 安梦培 冯贻东 申秀萍[2] 胡金芳[2] YAN Chen;DI Zhi-quan;ZHU Zhen-na;HUO Xuan;AN Meng-pei;FENG Yi-dong;SHEN Xiu-ping;HU Jin-fang(Department of Pharmacy, Tianjin Medical University General Hospital,Tianjin 300052,China;Tianjin Institute of Pharmaceutical Research New Drug Assessment Co. Ltd, Tianjin 300301,China;Shenzhen Haiwang Bioengineering Co., Ltd, Shenzhen 518057,China)

机构地区：[1]天津医科大学总医院药剂科,天津300052 [2]天津药物研究院新药评价有限公司,天津300301 [3]深圳市海王生物工程股份有限公司,广东深圳518057

出　　处：《现代药物与临床》2019年第7期1947-1951,共5页Drugs & Clinic

基　　金：国家科技重大新药创制项目(2015ZX09501004);天津市科技计划项目(17ZXXYSY00020)

摘　　要：目的探讨岩藻聚糖硫酸酯FV对大鼠的抗血栓作用。方法将60只Wistar大鼠随机分为对照组、岩藻聚糖硫酸酯FV 20、10、5、2.5 mg/kg组和低分子肝素钙注射液(LMWHC)213 IU/kg组,每组各10只。分别在下腔静脉血栓模型、体外血栓模型和动静脉旁路血栓模型中研究FV的抗血栓作用,比较血栓干湿质量并计算血栓抑制率。结果 FV 20、10、5、2.5mg/kg能够显著降低大鼠下腔静脉血栓、体外形成的血栓、动静脉旁路中血栓的干湿质量,对血栓湿质量的抑制率最高可达97.4%、94.3%、51.2%,对血栓干质量的抑制率最高可达91.8%、96.6%、64.0%,有明显的抑制血栓形成作用。结论 FV能够抑制血栓形成,量效关系好,具有开发为抗血栓药的良好前景。Objective To explore the antithrombotic effect of fucoidan from fucus vesiculosus FV on rats. Methods Wistar rats(60)were randomly divided into control group, FV 20, 10, 5, and 2.5 mg/kg groups, and Low-Molecular-Weight Heparins Calcium Injection(LMWHC) group, and each group had 10 rats. The anti-thrombotic effects of FV were studied in inferior vena cava thrombosis model, external thrombosis model, and arteriovenous bypass thrombosis model. Dry and wet mass of thrombosis were compared, and the inhibition rate of thrombosis was calcaulted. Results FV 20, 10, 5, and 2.5 mg/kg could significantly reduce the wet weight and dry mass of inferior vena cava thrombosis, external thrombosis, thrombosis in arteriovenous bypass in rats. The highest inhibition rate of wet mass of thrombosis was 97.4%, 94.3%, and 51.2%, and the highest inhibition rate of dry mass of thrombosis was 91.8%, 96.6%, and 64.0%. Conclusion FV can inhibit the produce of thrombosis, and has a good dose-effect relationship. It has a good prospect to be developed as antithrombotic drugs.

关 键 词：岩藻聚糖硫酸酯FV 抗血栓 下腔静脉血栓模型 体外血栓模型 动静脉旁路血栓模型 

分 类 号：R965[医药卫生—药理学]