麝香保心丸联合依诺肝素钠治疗急性心肌梗死的临床研究  

Clinical study on Shexiang Baoxin Pills combined with enoxaparin sodium in treatment of acute myocardial infarction

作　　者：徐亚宁 刘波 邹勇 XU Ya-ning;LIU Bo;ZOU Yong(Department of Internal Medicine-Cardiovascular, Affiliated Hospital of Jianghan University, Wuhan Sixth Hospital, Wuhan 430015,China)

机构地区：[1]江汉大学附属医院武汉市第六医院心血管内科

出　　处：《现代药物与临床》2019年第7期1993-1996,共4页Drugs & Clinic

摘　　要：目的探讨麝香保心丸联合依诺肝素钠注射液治疗急性心肌梗死的临床疗效。方法选择2016年1月-2018年1月江汉大学附属医院收治的104例急性心肌梗死患者作为研究对象,将所有患者按随机数字表法随机分为对照组和治疗组,每组各52例。对照组肌内注射依诺肝素钠注射液,7 500 IU/次,1次/d。治疗组在对照组治疗的基础上口服麝香保心丸,2粒/次,3次/d。两组均连续治疗10 d。观察两组的临床疗效,比较两组的心功能指标、血清心肌钙蛋白(cTnT)、肌酸激酶同工酶(CK-MB)、心肌营养素-1(CT-1)水平。结果治疗后,对照组和治疗组的总有效率分别为71.15%、90.38%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室收缩末期容积(LVESV)均明显下降,左心室射血分数(LVEF)均明显升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组心功能指标明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组血清cTnT、CK-MB、CT-1水平较治疗前有明显的升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组血清cTnT、CK-MB水平低于对照组,血清CT-1水平高于对照组,两组比较差异有统计学意义(P<0.05)。结论麝香保心丸联合依诺肝素钠注射液治疗急性心肌梗死具有较好的临床疗效,能够改善心功能,安全性较好,具有一定的临床推广应用价值。Objective To study the clinical efficacy of Shexiang Baoxin Pills combined with Enoxaparin Sodium Injection in treatment of acute myocardial infarction. Methods Patients(104 cases) with acute myocardial infarction in Affiliated Hospital of Jianghan University from January 2016 to January 2018 were randomly divided into control and treatment groups, and each group had 52 cases.Patients in the control group were iv administered with Enoxaparin Sodium Injection, 7 500 IU/time, once daily. Patients in the treatment group were po administered with Shexiang Baoxin Pills on the basis of the control group, 2 grains/time, three times daily.Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and cardiac function indexes, the serum levels of the cTnT, CK-MB, and CT-1 in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.15% and 90.38%, respectively, and there was difference between two groups(P < 0.05). After treatment, LVEDD, LVESD, and LVESV in two groups were significantly decreased, but LVEF in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the cardiac function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05).After treatment, the serum levels of the cTnT, CK-MB, and CT-1 in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the levels of cTnT and CK-MB in the treatment group were significantly lower than those in the control group, but the levels of CT-1 in the treatment group were significantly higher than that in the control group, with significant difference between two groups(P < 0.05). Conclusion Shexiang Baoxin Pills combined with Enoxaparin Sodium Injection has clinical curative effect in treatment of acute myocardial infarction, can improve cardiac funct

关 键 词：麝香保心丸 依诺肝素钠注射液 急性心肌梗死 心功能 左心室舒张末期内径 血清指标 心肌钙蛋白 肌酸激酶同工酶 心肌营养素-1 

分 类 号：R972[医药卫生—药品]