空气污染暴露与妊娠期糖尿病关系的研究  

Relationship between air pollution and gestational diabetes

作　　者：武丽[1] 缪华章[1] 陈乐 祝新红 钟银莉 纪存委[1] 徐昊立 马远珠[1] 梁志江[1] 赵庆国 WU Li;MIAO Hua Zhang;CHEN Le;ZHU Xin Hong;ZHONG Yin Li;JI Cun Wei;XU Hao Li;MA Yuan Zhu;LIANG Zhi Jiang;ZHAO Qing Guo(Guangdong Women and Children Hospital, Guangzhou 511442 , China;Guangdong Provincial Institute of Family Planning Science and Technology, Guangzhou 510000, China)

机构地区：[1]广东省妇幼保健院,广州511442 [2]广东省计划生育科学技术研究所,广州510000

出　　处：《中国妇幼卫生杂志》2019年第4期11-15,共5页Chinese Journal of Women and Children Health

基　　金：全国重点地区环境与健康专项调查技术文件编写与验证子项目:环境与生殖健康调查方法【21111011101EHH(2011)-208】

摘　　要：目的探讨大气污染物与妊娠期糖尿病是否存在相关性,提出大气污染可能是妊娠期糖尿病的一个影响因素。方法收集2015-2016年期间广东省妇幼保健院产检的4941名孕妇的糖耐量试验结果,并搜集同期的大气污染物数据,包括PM2.5、PM10、SO2和NO2等指标,采用Logistic回归分析大气污染物与糖耐量水平的关系。结果多因素Logistic回归分析发现,PM2.5为(39.43~48.51)μg/m3(RR=1.212,95%CI:1.041~1.537)和>48.51μg/m3(RR=1.298,95%CI:1.031~1.603)、PM10为(56.72~69.36)μg/m3(RR=1.273,95%CI:1.071~1.689)和>69.36μg/m3(RR=1.359,95%CI:1.086~1.777)、NO2为(45.81~49.07)μg/m3(RR=1.271,95%CI:1.093~1.671)和>49.07μg/m^3(RR=1.366,95%CI:1.125~1.728)、SO2>17.13μg/m3(RR=1.262,95%CI:1.003~1.507)是妊娠期糖尿病发生的危险因素。结论PM2.5、PM10、SO2和NO2可以影响孕妇妊娠期血糖水平,是妊娠期糖尿病发生的危险因素。因此,孕妇应尽量避免去污染比较严重的环境,从而降低空气污染对血糖水平的影响。Objective To study the relationship between air pollution and gestational diabetes,and to suggest air pollution as a risk factor for gestational diabetes. Methods The data of glucose oral glucose tolerance test of 4941 pregnant women from Guangdong Women and Children Hospital during 2015 and 2016,and the data of air pollutants( PM2. 5,PM10,SO2,NO2) were collected at the same time. The relationship between air pollution and glucose tolerance was analyzed by logistic regression analysis. Results Multivariate logistic regression analysis revealed that PM2. 5=( 39. 43-48. 51)μg/m3( RR = 1. 212,95% CI: 1. 041-1. 537),> 48. 51μg/m3( RR = 1. 298,95% CI: 1. 031-1. 603),PM10=( 56. 72-69. 36)μg/m^3( RR = 1. 273,95% CI: 1. 071-1. 689),> 69. 36μg/m^3( RR = 1. 359,95% CI: 1. 086-1. 777),NO2=( 45. 81-49. 07)μg/m3( RR = 1. 271,95% CI: 1. 093-1. 671),> 49. 07μg/m3( RR = 1. 366,95% CI: 1. 125-1. 728),SO2> 17. 13μg/m3( RR = 1. 262,95% CI: 1. 003-1. 507) were the risk factors of gestational diabetes. Conclusion PM2. 5,PM10,SO2,and NO2 can affect blood glucose levels during pregnancy and are risk factors for gestational diabetes mellitus. Therefore,pregnant women should try to avoid the seriously polluted environment,which can reduce the impact of air pollution on the blood glucose levels.

关 键 词：空气污染 妊娠期糖尿病 危险因素 

分 类 号：R714.256[医药卫生—妇产科学]