薄型子宫内膜不孕症雌激素药物治疗的疗效研究  

Therapeutic effect of estrogen on thin endometrial infertility

作　　者：肖静[1] 庄元[1] 郭晨[1] 江如[1] XIAO Jing;ZHUANG Yuan;GUO Chen(Jiangxi Maternal and Child Health Hospital Reproductive Health Division ,Jiangxi Nanchang 330006,China)

机构地区：[1]江西省妇幼保健院生殖健康科

出　　处：《江西医药》2019年第7期721-723,743,共4页Jiangxi Medical Journal

基　　金：江西省卫生计生委科技计划,编号20195471

摘　　要：目的探究薄型子宫内膜不孕症雌激素药物治疗的疗效.方法选择我院门诊部2018年1月-2018年12月收治的160例薄型子宫内膜不孕症患者,根据密封信封法随机分为4组,每组40例,A组患者予补佳乐口服治疗,B组患者予小剂量补佳乐+雌二醇贴片治疗,C组患者予小剂量补佳乐+芬吗通治疗,D组患者予结合雌激素片口服治疗,分析4组患者治疗前后子宫内膜厚度变化、治疗费用、不良反应、妊娠率及流产率情况差异.结果治疗后,4组子宫内膜厚度均增加,C组子宫内膜厚度大于其余3组,B组子宫内膜厚度大于A组、D组,差异有统计学意义(P<0.05),A、D两组治疗10d后子宫内膜厚度差异无统计学意义(P>0.05);B、C两组内膜厚度达8mm时间均短于A、D两组,差异有统计学意义(P<0.05);B组与C组间、A组与D组间内膜厚度达8mm时间比较差异无统计学意义(P>0.05);药物治疗费用由高至低依次为D组、B组、C组、A组;4组不良反应发生率及妊娠率比较差异无统计学意义(P>0.05).结论薄型子宫内膜不孕症雌激素药物治疗中,联合用药效果更好,达到8mm的用药天数更短,用药10d的内膜更厚.Objective To study the effect of the treatment of thin endometrial infertility. Methods 160 patients with thin endometrial infertility were randomly divided into four groups according to the sealed envelope method. In group C, the patients were treated with a small dose of good-dose-plus-fene, and the patients in group D were treated with oral therapy. The changes of the thickness of the endometrium before and after treatment, the treatment cost, the adverse reaction, the pregnancy rate and the rate of abortion were analyzed. Difference. Results After treatment, the endometrial thickness in group C was higher than that of the other three groups, the thickness of endometrium in group B was larger than that of group A and group D, the difference was statistically significant (P<0.05). There was no significant difference in endometrial thickness between group D and group D 10 days after treatment (P>0.05). The time of intimal thickness to 8mm in group C was shorter than that of group A(P<0.05), and there was no significant difference between group A and group D(P>0.05). The order of the cost of drug treatment from high to low is There was no significant difference in the incidence of adverse reactions and pregnancy rate among group D, group B, group C and group A(P>0.05). Conclusion In the treatment of thin endometrium infertility, the effect of combined use is better, the days to 8mm is shorter and the thickness of endometrium is thicker after 10 days.

关 键 词：薄型子宫内膜不孕症 药物治疗 疗效 

分 类 号：R711.6[医药卫生—妇产科学]