尿蛋白质组学在心血管疾病生物标志物研究中的应用  

Application of urinary proteomics in study of cardiovascular disease biomarkers

作　　者：张霞[1] 孙长青[2] 吴红星 宋雷 赵志云[1] 李振超 管明秀 Xia Zhang;Chang-qin Sun;Hong-xing Wu;Lei Song;Zhi-yun Zhao;Zhen-chao Li;Ming-xiu Guan(Department of Cardiology, Baodi College of Clinical Medicine, Tianjin Medical University, Tianjin 301800, China;Department of Neurosurgery, Baodi College of Clinical Medicine, Tianjin Medical University, Tianjin 301800, China;National Center for Protein Sciences, Beijing 102200,China;Department of Clinical Laboratory, Baodi College of Clinical Medicine,Tianjin Medical University, Tianjin 301800, China)

机构地区：[1]天津医科大学宝坻临床学院心内科,天津301800 [2]天津医科大学宝坻临床学院神经外科,天津301800 [3]北京国家蛋白质科学中心,北京102200 [4]天津医科大学宝坻临床学院检验科,天津301800

出　　处：《中国现代医学杂志》2019年第16期48-53,共6页China Journal of Modern Medicine

摘　　要：当前心血管疾病的患病率及病死率处于上升阶段,因此筛选出新的心血管疾病生物标志物尤为重要。传统上,血液一直是研究最广泛的生物标志物来源。近年来,随着尿蛋白质组学更广泛地应用于临床,尿液作为生物标志物的来源引起了学术界的广泛关注,这将有助于更好地了解心血管疾病的病理生理,定义新的用于预测、诊断和指导治疗的生物标志物,并有助于确定新的治疗靶点。该综述介绍了当前尿蛋白质组学的研究进展和已知的心血管疾病尿液中特征性标志物研究的主要发现。The prevalence and mortality rate of cardiovascular disease in China is still on the rise, so it is especially important to screen out new cardiovascular disease biomarkers. Traditionally, blood has been the most widely studied source of biomarkers. In recent years, urinary proteomics has become more widely used in clinically relevant issues, and the use of urine as a biomarker has attracted widespread attention in academia. This can help to better understand pathophysiological process of cardiovascular disease, allow the definition of new biomarkers for predicting, diagnosing, guide clinical treatment, and help identify new therapeutic targets. This paper describes the current research advance in urinary proteomics and the major finding in the study of characteristic markers in the urine of known cardiovascular diseases, and prospects for future development.

关 键 词：蛋白质组学 心血管疾病 尿 

分 类 号：R543[医药卫生—心血管疾病]