血管回声跟踪技术评价颈动脉硬化与肠道菌群失调的相关性研究  

Relevance between intestinal flora disorder and carotid atherosclerosis by ET

作　　者：董晓柳[1] 崔璐莎 王增英[3] 赵蕊[2] 刘海艳 张秀清[1] 佟玲[1] Xiao-liu Dong;Lu-sha Cui;Zeng-ying Wang;Rui Zhao;Hai-yan Liu;Xiu-qing Zhang;Ling Tong(Tangshan People's Hospital, Tangshan, Hebei 063001, China;Kailuan Mental Health Center,Tangshan, Hebei 063002, China;Rehabilitation Hospital, Kailuan General Hospital,Tangshan, Hebei 063000, China)

机构地区：[1]唐山市人民医院,河北唐山063001 [2]开滦精神卫生中心,河北唐山063002 [3]开滦总医院康复医院,河北唐山063000

出　　处：《中国现代医学杂志》2019年第16期90-94,共5页China Journal of Modern Medicine

基　　金：河北省医学科学研究重点课题(No:20181217)

摘　　要：目的应用血管回声跟踪技术(ET)评价颈动脉硬化与肠道菌群失调相关性。方法选取2017年7月—2018年4月唐山市人民医院接诊的117例颈动脉粥样硬化患者作为观察组,另取同期健康体检人群117例作为对照组。两组行血管ET评价和肠道菌群检测。结果观察组僵硬度、压力应变弹性系数、放射波增压指数、脉搏波传导速度、内膜中层厚度、消化链球菌、葡萄球菌、肠球菌及大肠埃希菌高于对照组(P<0.05);观察组顺应性、双歧杆菌、乳酸杆菌及酵母菌低于对照组(P<0.05)。颈动脉粥样硬化指标(僵硬度、压力应变弹性系数、放射波增压指数、脉搏波传导速度及内膜中层厚度)与肠道菌群(双歧杆菌、乳酸杆菌、酵母菌)呈负相关(P<0.05),与肠道菌群(消化链球菌、葡萄球菌、肠球菌、大肠埃希菌)呈正相关(P<0.05)。颈动脉粥样硬化指标(顺应性)与肠道菌群(双歧杆菌、乳酸杆菌、酵母菌)呈正相关,与肠道菌群(消化链球菌、葡萄球菌、肠球菌、大肠埃希菌)呈负相关(P<0.05)。结论血管ET技术评价颈动脉粥样硬化的临床价值较高,且与肠道菌群的关系密切,值得临床推广应用。Objective To investigate relevance between intestinal flora disorder and carotid atherosclerosis by ET. Methods Totally 117 patients with carotid atherosclerosis were selected in hospital from July 2017 to April 2018 as observation group. 117 health checkup people were selected at same period as control group. All people treated echo tracking technique evaluation and intestinal flora detection. Results Stiffness, pressure strain elasticity coefficient, radio wave pressure index, pulse wave conduction velocity, middle intima thickness, streptococcus, staphylococci, enterococci, escherichia coli in observation group were higher than those in control group (P < 0.05). Compliance, bifidobacteria, lactobacillus and yeast in observation group were lower than those in control group (P < 0.05). Carotid atherosclerosis indicators (stiffness, pressure-strain elasticity coefficient, radiation wave pressure index, pulse wave velocity and intima-media thickness) were negatively correlated with intestinal flora (bifidobacterium, lactobacillus, yeast)(P < 0.05), and intestinal flora (digestive streptococcus, staphylococcus, enterococcus, Escherichia coli). There was a positive correlation (P < 0.05). The index of carotid atherosclerosis (compliance) was positively correlated with intestinal flora (bifidobacterium, lactobacillus, yeast) and negatively correlated with intestinal flora (digestive streptococcus, staphylococcus, enterococcus, Escherichia coli)(P < 0.05). Conclusions The clinical value of vascular ET in evaluating carotid atherosclerosis is high, and it is closely related to intestinal flora, which is worthy of clinical application.

关 键 词：颈动脉疾病 动脉粥样硬化 肠杆菌科 

分 类 号：R454.3[医药卫生—治疗学]