针刺配合复方血栓通治疗视网膜静脉阻塞的临床疗效及对外周血VEGF及ET-1表达的影响  

Clinical Efficacy of Acupuncture plus Compound Xueshuantong for Retinal Vein Occlusion and Its Effect on the Expressions of VEGF and ET-1 in Peripheral Blood

作　　者：王宇 孔德宁 WANG Yu;KONG De-ning(Daqing No.5 Hospital, Daqing 163711, China)

机构地区：[1]大庆市第五医院

出　　处：《上海针灸杂志》2019年第8期883-887,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：黑龙江省中医药管理科研项目(ZHY12-W132)

摘　　要：目的观察针刺配合复方血栓通治疗气滞血瘀型视网膜静脉阻塞的临床疗效,及对外周血血管内皮生长因子(vascular endothelial growth factor,VEGF)及血清内皮素-1(endothelin-1,ET-1)表达方面的影响,以探讨其作用机制.方法收集气滞血瘀型视网膜静脉阻塞患者78例,根据随机数字表法分为对照组和观察组,每组39例.两组在常规支持治疗基础上,对照组口服复方血栓通,观察组在对照组基础上加针刺治疗,疗程为8周.比较两组患者治疗后的疗效及视力恢复情况,测定治疗前后血清中VEGF及ET-1的表达.结果两组治疗前视力比较差异无统计学意义(P>0.05),两组治疗后视力明显提高,且观察组治疗后视力明显高于对照组,差异具有统计学意义(P<0.05);观察组总有效率优于对照组,差异具有统计学意义(P<0.05);两组治疗前VEGF、ET-1表达比较差异无统计学意义(P>0.05),两组治疗后VEGF、ET-1表达明显下降,且观察组明显低于对照组,差异具有统计学意义(P<0.05).结论针刺配合复方血栓通对气滞血瘀型视网膜静脉阻塞的患者疗效显著,可以明显提高患者视力,并有效改善机体VEGF、ET-1细胞因子的表达水平.Objective To observe the clinical efficacy of acupuncture plus compound Xueshuantong capsules in treating retinal vein occlusion (RVO) due to qi-blood stagnation, and its effect on the expressions of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in peripheral blood, for discussing the action mechanism. Method Seventy-eight patients with RVO due to qi-blood stagnation were divided into a control group and an observation group by random number table method, with 39 cases in each group. Based on the conventional supportive treatment, the control group was given oral administration of compound Xueshuantong, while the observation group was given acupuncture treatment in addition to the intervention for the control group. The treatment course was 8 weeks. The therapeutic efficacies and improvements of vision of the two groups were compared. The expressions of VEGF and ET-1 in serum were detected before and after treatment. Result There was no significant difference in vision between the two groups before treatment (P>0.05);the observation group was superior to the control group comparing vision after treatment, and the difference was statistically significant (P<0.05). The total effective rate in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in the expressions of VEGF and ET-1 between the two groups (P>0.05);the expressions of VEGF and ET-1 declined obviously after treatment in the two groups, and the expressions in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the expression of ET-1 between the two groups before treatment (P>0.05);after treatment, the expression of ET-1 in the observation group was significantly lower than that in the control group (P<0.05). Conclusion Acupuncture plus compound Xueshuantong can produce significant efficacy in treating RVO due to qi-blood stagnation. It

关 键 词：针刺疗法 针药并用 视网膜静脉阻塞 血管内皮生长因子 血清内皮素-1 气滞血瘀 

分 类 号：R246.82[医药卫生—针灸推拿学]