BOLD-MRI评价含碘对比剂对糖尿病肾病兔肾脏氧含量的影响  

Impact of iodinated contrast agents on blood oxygenation level of renal in rabbits with diabetic nephropathy using BOLD-MRI

作　　者：王佳欢[1] 周菲[1] 魏宝春[1] 林红[1] WANG Jiahuan;ZHOU Fei;WEI Baochun;LIN Hong(Imaging Center, Jilin Central Hospital, Jilin 132000, China)

机构地区：[1]吉林市中心医院影像中心

出　　处：《中国医学影像技术》2019年第8期1164-1168,共5页Chinese Journal of Medical Imaging Technology

基　　金：吉林省卫生计生青年科技骨干培养计划项目(2016Q003)

摘　　要：目的采用BOLD-MRI评价含碘对比剂对糖尿病肾病兔肾脏氧含量的影响。方法对4组糖尿病肾病实验兔(每组8只)分别注射不同浓度含碘对比剂(200、240、300、350mgI/ml,命名为200亚组、240亚组、300亚组、350亚组),对照组(n=8)注射对应剂量生理盐水,注射后1、24、48、72h进行BOLD-MR检查,测量实验兔肾皮质、外髓和内髓的R2^*值,比较不同组间及时间点间R2*值的差异。结果注射对比剂后1h,各组兔肾皮质、外髓和内髓R2^*值均升高,24h升至最高,之后开始下降。注射对比剂后各时间点,350亚组、300亚组、240亚组、200亚组与对照组间肾皮质、外髓、内髓的R2^*值总体差异均有统计学意义(P均<0.001),随碘对比剂浓度增高R2^*值逐渐增高,350亚组R2^*值最高。注射后24h,350亚组中,肾外髓R2^*值高于皮质和内髓(P均<0.05)。结论含碘对比剂可明显影响糖尿病肾病实验兔肾脏氧含量,其变化存在一定规律;BOLD-MRI可为临床合理应用对比剂和监测肾功能提供更多辅助信息。Objective To evaluate the impact of iodinated contrast media on renal oxygenation content in rabbits with diabetic nephropathy using BOLD-MRI. Methods Totally 32 rabbits with diabetic nephropathy (experimental group) were randomly divided into 4 groups (each n =8) and received iodinated contrast media with different concentration (200, 240, 300, 350 mgI/ml, named 200 subgroup, 240 subgroup, 300 subgroup and 350 subgroup, respectively). Rabbits in control group (8 normal rabbits) received normal saline (NS). BOLD-MRI was performed at 1, 24, 48 and 72 h after injection, and R2^* value of renal cortex, extramedulla and intramedulla of the rabbits were measured and compared among different groups and different time points. Results One hour after administration of iodinated contrast media, R2^* value of the renal cortex, extramedulla and intramedulla increased in experimental group, reaching their peak value at 24 h and then declined. Significant differences of R2^* value were found among 4 subgroups at all time points after injection (all P <0.001), and with the increase of iodine concentration, R2^* value increased, with the highest R2^* value observed in 350 subgroup. In experimental group, R2^* value of the extramedulla was higher than the cortex and intramedulla 24 h after injection in 350 subgroup (both P <0.05). Conclusion Iodinated contrast media can significantly affect the oxygen content of renal extramedulla in diabetic nephropathy rabbits, and the changes may have certain rules. BOLD-MRI can provide auxiliary information for rational clinical application of contrast agent and monitoring renal function.

关 键 词：糖尿病肾病 碘化合物 对比剂 兔 血氧水平依赖 磁共振成像 

分 类 号：R587.1[医药卫生—内分泌] R445.2[医药卫生—内科学]