儿童肺炎支原体感染合并Stevens-Johnson综合征1例并文献复习  

Mycoplasma Pneumoniae Infection Associated with Stevens-Johnson Syndrome in Children:a Case Report and Literature Review

作　　者：巴宏军[1] 徐玲玲[2] 汪玓 李轩狄[1] 林约瑟[1] 王慧深[1] 覃有振[1] BA Hong-jun;XU Ling-ling;WANG Di;LI Xuan-di;LIN Yue-se;WANG Hui-shen;QIN You-zhen(Department of Pediatric Cardiology,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Pediatric Intensive Care Unit,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院心血管儿科,广州510080 [2]中山大学附属第一医院PICU,广州510080

出　　处：《实用临床医学（江西）》2019年第7期47-49,共3页Practical Clinical Medicine

摘　　要：目的提高对儿童肺炎支原体感染合并Stevens-Johnson综合征的认识。方法回顾分析1例儿童肺炎支原体感染合并Stevens-Johnson综合征的临床资料,并进行相关文献复习。结果本例患者起病较急,无明确药物过敏史,颈部、胸前、腹部、背部可见散在大小不等靶型红疹,稍凸出皮面,部分融合成片,眼睛及尿道口红肿伴渗出;具有前期的呼吸道感染病史,肺炎支原体抗体阳性,红细胞沉降率及血清IgE高,且存在细胞免疫紊乱。给予及时的免疫反应阻断、阿奇霉素治疗,并进行皮肤、黏膜护理后症状改善,痊愈出院。结论对于Stevens-Johnson综合征患者临床应及时识别其病因,予针对性治疗,可改善预后,减少致残、致死率。Objective To improve the understanding of mycoplasma pneumoniae infection associated with Stevens-Johnson syndrome in children. Methods Clinical data of a child with mycoplasma pneumoniae infection and Stevens-Johnson syndrome were retrospective analyzed,and the relevant literature was reviewed. Results The acute onset child had a previous history of respiratory tract infection,but had no clear history of drug allergy.Various sizes of target-type red rash slightly protruded skin surface and partially fused into a piece in the neck,chest,abdomen and back of the child.Furthermore,the eyes and urethral orifice were red and swollen with an effusion.Moreover,the child was positive for mycoplasma pneumonia with increased erythrocyte sedimentation rate and serum IgE levels and disordered cellular immunity.After timely immunoblocking,azithromycin treatment and skin and mucosal care,the child achieved symptomatic improvement,eventually recovered and was discharged from the hospital. Conclusion Etiology identification and targeted treatment should be performed in time to improve the prognosis and reduce the incidence of disability and death in children with Stevens-Johnson syndrome.

关 键 词：STEVENS-JOHNSON综合征 肺炎支原体 渗出性多形红斑 病因 儿童 

分 类 号：R758.25[医药卫生—皮肤病学与性病学] R726.5[医药卫生—临床医学]