中年无症状性脑梗死事件相关电位P300变化及其与认知功能的相关性研究  

Changes of Event-related Potential P300 in Middle-aged Patients with Asymptomatic Cerebral Infarction and Its Correlation with Cognitive Function

作　　者：董淑欣[1] 吴成吉[1] 滕立志 李丛言[1] DONG Shu-xin;WU Cheng-ji;TENG Li-zhi;LI Cong-yan(Fourth Department of Neurology,First Affiliated Hospital of Jiamusi University,Jiamusi 154007,Heilongjiang,China;School of Clinical Medicine,Jiamusi University,Jiamusi 154007,Heilongjiang,China)

机构地区：[1]佳木斯大学附属第一医院神经四科,黑龙江佳木斯154007 [2]佳木斯大学临床医学院,黑龙江佳木斯154007

出　　处：《医学信息》2019年第16期105-106,共2页Journal of Medical Information

基　　金：黑龙江省大学生创新创业训练计划项目（编号：201810222032）

摘　　要：目的探讨中年无症状性脑梗死事件相关电位P300变化及与认知功能的相关性。方法选择2017年5月~2018年10月我院收治的中年无症状性脑梗死患者71例设为观察组,选择同期治疗的非脑梗死患者65例设为对照组。两组入院后均采用NEUROPACK型肌电图及诱发电位仪完成事件相关电位P300测定,采用HAMD、MMSE检查量表评估认知功能,并分析中年无症状性脑梗死事件电位P300与认知功能相关性。结果观察组P3L、HAMD评分高于对照组[(384.57±24.71)vs(350.51±24.59)、(23.23±2.31)分vs(14.51±1.95)分],Amp、MMSE评分低于对照组[(11.67±2.15)vs(16.89±3.49)、(20.12±0.34)分vs(24.69±0.62)分],差异有统计学意义(P<0.05)。中年无症状性脑梗死事件电位P300与认知功能相关性分析结果表明:P3L与HAMD评分呈正相关性(r=0.693,P=0.017),MMSE评分呈负相关性(r=-0.392,P=0.033);事件电位Amp与HAMD评分呈负相关性(r=-0.592,P=0.039),MMSE评分呈正相关性(r=0.593,P=0.044)。结论中年无症状性脑梗死患者常伴有相关电位P300变化,表现为潜伏期延长及波幅下降,与认知功能存在相关性,能评估患者疾病严重程度。Objective To investigate the changes of event-related potential P300 in middle-aged asymptomatic cerebral infarction and its correlation with cognitive function.Methods 71 middle-aged patients with asymptomatic cerebral infarction treated from May 2017 to October 2018 were selected as observation group,and 65 non-cerebral infarction patients treated at the same time were selected as control group.Event-related potential P300 was measured by NEUROPACK electromyography and evoked potential instrument in both groups after admission.Cognitive function of the two groups was evaluated by HAMD and MMSE scales.Results The P3L and HAMD in the observation group were higher than that in the control group[(384.57±24.71)vs(350.51±24.59),(23.23±2.31)scores vs(14.51±1.95)scores],the Amp and MMSE were lower than that in the control group[(11.67±2.15)vs(16.89±3.49),(20.12±0.34)scores vs(24.69±0.62)scores],the difference was statistically significant(P<0.05).The correlation analysis between event-related potential P300 and cognitive function in middle-aged patients with asymptomatic cerebral infarction showed that the P3L was positively correlated with the HAMD score(r=0.693,P=0.017),the MMSE score was negatively correlated(r=-0.392,P=0.033);the Amp was negatively correlated with the HAMD score(r=-0.592,P=0.039),the MMSE score was positively correlated(r=0.593,P=0.044).Conclusion Middle-aged patients with asymptomatic cerebral infarction are often accompanied by changes of correlation potential P300,which is characterized by prolonged latency and decreased amplitude.It is correlated with cognitive function and can evaluate the severity of the disease.

关 键 词：无症状性脑梗死 相关电位P300 认知功能 

分 类 号：R395.1[哲学宗教—心理学]