复方芪麻胶囊结合辛伐他汀治疗气虚痰浊型颈动脉粥样硬化患者的临床效果分析  

Clinical Effect of Compound Qima Capsule Combined with Simvastatin in Treatment of Carotid Atherosclerosis with Qi Deficiency and Phlegm Turbidity

作　　者：吕娟 LYU Juan(Guangdong Second Hospital of Traditional Chinese Medicine,Guangzhou 510095,China)

机构地区：[1]广东省第二中医院

出　　处：《中国医学创新》2019年第22期80-83,共4页Medical Innovation of China

基　　金：广东省中医药局科研项目(20191027)

摘　　要：目的:探讨复方芪麻胶囊结合辛伐他汀治疗气虚痰浊型颈动脉粥样硬化患者的临床效果。方法:选取2017年3月-2018年10月本院收治的气虚痰浊型颈动脉粥样硬化患者62例。按照随机数字表法将其分为研究组和对照组,各31例。对照组予以辛伐他汀治疗,研究组予以复方芪麻胶囊结合辛伐他汀治疗。比较两组颈动脉内膜-中膜厚度(IMT)、颈动脉粥样硬化斑块面积、血脂代谢指标(TC、TG、HDL-C、LDL-C)、丙氨酸转氨酶(ALT)、血管内皮功能指标(LOX-1、ox-LDL、APN)、炎性因子水平(MMP-9、TNF-α、IL-6)。结果:干预后,研究组IMT、斑块面积均小于对照组(P<0.05);研究组TC、TG、LDL-C、ox-LDL、LOX-1、IL-6、TNF-α、MMP-9均低于对照组,HDL-C、APN高于对照组,差异均有统计学意义(P<0.05);研究组ALT均低于干预前及对照组,但对照组高于干预前,差异均有统计学意义(P<0.05)。结论:复方芪麻胶囊结合辛伐他汀治疗气虚痰浊型颈动脉粥样硬化患者,可抑制其炎症反应、降脂、保护血管内皮功能,且安全性较高,可进一步降低或延缓血管损伤程度。Objective:To investigate the clinical effect of Compound Qima Capsule combined with Simvastatin in treatment of carotid atherosclerosis of Qi deficiency and phlegm turbidity type.Method:A total of 62 carotid atherosclerosis patients with Qi deficiency and phlegm turbidity from March 2017 to October 2018 in our hospital were selected.According to the random number table method,they were divided into study group and control group,31 cases in each group.The control group was treated with Simvastatin,while study group was treated with Compound Qima Capsule combined with Simvastatin.The carotid intima-media thickness(IMT),carotid atherosclerotic plaque area,lipid metabolism index(TC,TG,HDL-C,LDL-C),alanine aminotransferase(ALT),vascular endothelial function index(LOX-1,ox-LDL,APN),inflammatory factor level(MMP-9,TNF-α,IL-6)between two groups were compared.Result:After intervention,IMT and plaque area in study group were smaller than those of control group(P<0.05),the TC,TG,LDL-C,ox-LDL,LOX-1,IL-6,TNF-α and MMP-9 in study group were lower than those of control group,while HDL-C and APN were higher than those of control group,the differences were statistically significant(P<0.05).the ALT in study group were lower than those of before intervention and control group,but that in control group was higher than that of before intervention,the differences were statistically significant(P<0.05).Conclusion:Compound Qima Capsule combined with Simvastatin in treatment of carotid atherosclerosis patients with Qi deficiency and phlegm turbidity can inhibit inflammation,reduce lipid,protect vascular endothelial function,and has high safety,which can further reduce or delay the degree of vascular injury.

关 键 词：颈动脉粥样硬化 气虚痰浊型 复方芪麻胶囊 辛伐他汀 

分 类 号：R543.4[医药卫生—心血管疾病]