高血压病中医证型与眼底血管病变、颈动脉粥样硬化、胰岛素水平的相关性分析  

An analysis of correlation between TCM syndromes of hypertension and fundus vascular lesions, carotid atherosclerosis and insulin level

作　　者：张小娟 蒋珍秀[2] 邹蕴[3] 李兴辉 陈雅彬 刘翠清 王小琴 Zhang Xiaojuan

机构地区：[1]甘肃中医药大学附属医院,甘肃兰州730000 [2]兰州大学第一医院,甘肃兰州730000 [3]新疆军区总医院,新疆乌鲁木齐830001 [4]新疆维吾尔自治区第五人民医院,新疆乌鲁木齐830001

出　　处：《中医临床研究》2019年第16期11-14,共4页Clinical Journal Of Chinese Medicine

基　　金：甘肃省青年科技计划,项目编号:1606RJYA233

摘　　要：目的:探讨原发性高血压中医证型与胰岛素水平、血糖、颈动脉粥样硬化、眼底分级之间的相关性。方法:将高血压患者中医辨证分型为肝火亢盛、阴虚阳亢、痰湿壅盛、阴阳两虚,测空腹胰岛素水平、空腹血糖,经彩色多普勒测试患者双侧颈动脉内膜厚度及行眼底检查,行高血压中医证型与上述指标的相关性分析。结果:胰岛素水平在高血压中医证型间存在差异,肝火亢盛证组的胰岛素水平高于其他证型组;总胆固醇在高血压各证型间存在差异,且阴虚阳亢证组的总胆固醇高于其他证型组;眼底病变情况在高血压证型间比较有统计学意义,肝火亢盛证组发生眼底1级病变所占比例最高;阴阳两虚证发生2级病变所占比例高;高血压各证型间在动脉壁内中膜厚度(Intima-media Thickness,IMT)、最大峰值血流速度(Peak Systolic Velocity,PSV)、舒张度末期最低血流速度(End Diastolic Velocity,EDV)、搏动指数(Pulsatility Index,PI)、阻力指数(Resistance Index,RI)差异不存在统计学意义。Objective: To investigate the correlation between TCM syndromes of essential hypertension and insulin levels, blood glucose, carotid atherosclerosis and fundus grading. Methods: Hypertensive patients were classified as Ganhuo Kangsheng (肝火亢盛), Yinxu Yangkang (阴虚阳亢), Tanshi Yongsheng (痰湿壅盛), Yinyang Liangxu (阴阳两虚). Fasting insulin level and glucose were tested, bilateral common carotid artery intima-media thickness and line fundus examination were tested by color Doppler. Relationships between TCM syndrome types of hypertension and the above indicators were analyzed. Results: There were differences in insulin levels between the TCM syndromes of hypertension, and the insulin levels in the Ganhuo Kangsheng group were higher than those in the other syndrome groups. The total cholesterol was different among the syndrome types of hypertension, and the total cholesterol was higher in the Yinxu Yangkang syndrome group. In other syndrome groups, the fundus lesions were statistically significant differences among the hypertensive syndrome types. The proportion of fundus grade 1 lesions was highest in the Ganhuo Kangshang group. The proportion of grade 2 lesions in the Yinyang Liangxu syndrome was highese. Intima-media thickness, peak systolic velocity, end diastolic velocity, the pulsatility index and resistance index showed no statistically significant differences among groups.

关 键 词：高血压 中医证型 胰岛素水平 颈动脉粥样硬化 眼底血管病变 相关性分析 

分 类 号：R259.441[医药卫生—中西医结合]