芪麻化浊汤对急性缺血性脑卒中患者颈动脉粥样硬化斑块及血清炎症因子的影响  

The effect of the Qima Huazhuo decoction on carotid atherosclerotic plaque and serum inflammatory factors in patients with acute ischemic stroke

作　　者：蔡飙[1] 叶瑞妍 张智琳[1] 林宏[1] 王书浩[1] Cai Biao

机构地区：[1]广州市中医医院

出　　处：《中医临床研究》2019年第16期62-64,共3页Clinical Journal Of Chinese Medicine

基　　金：广东省中医药局科研项目,编号20191027

摘　　要：目的:探讨芪麻化浊汤对急性缺血性脑卒中患者颈动脉粥样硬化斑块及血清炎症因子的影响。方法:选取2016年1月-2018年10月我院收治的172例急性缺血性脑卒中患者作为研究对象,将其随机分为研究组和对照组,每组86例,对照组给予常规治疗措施,研究组在常规治疗基础上给予芪麻化浊汤治疗。比较两组患者治疗前后血清炎症因子肿瘤坏死因子(Tumor Necrosis Factor-α,TNF-α)、C反应蛋白(C-reactive Protein,CRP)水平、颈动脉粥样硬化斑块指标的变化及不良反应发生情况。结果:治疗30天后,两组患者血清TNF-α和CRP水平较治疗前均显著下降(P<0.05),且研究组患者血清TNF-α和CRP水平较对照组患者下降更为显著(P<0.05)。治疗3个月后,两组患者的颈动脉粥样硬化斑块总面积(Total Plaque Area,TPA)和不稳定斑块数目较治疗前均显著降低(P<0.05),但内膜中层厚度(Intima-Media Thickness,IMT)虽有降低趋势,但差异无统计学意义(P>0.05),且研究组患者的TPA和不稳定斑块数目较对照组患者降低更为显著(P<0.05)。结论:在常规治疗基础上辅助芪麻化浊汤可明显降低急性缺血性脑卒中患者急性期血清炎症因子水平,并在一定程度上减轻颈动脉粥样硬化程度,有助于神经功能的恢复和短期预后的改善。Objective: To investigate the effects of the Qima Huazhuo decoction (芪麻化浊汤) on carotid atherosclerotic plaque and serum inflammatory factors in patients with acute ischemic stroke. Methods: 172 patients were randomly divided into the study group and control group, 86 cases in each group. The control group was given routine treatment, and the study group was given the Qima Huazhuo decoction more. Results: After 30 days, the levels of serum TNF-α and CRP in the two groups were significantly lower than those before treatment(P<0.05), and those in the study group were significantly lower than the control group(P<0.05). After 3 months, the number of TPA and unstable plaques in the two groups were significantly lower than those before treatment(P<0.05). IMT were decreased, while the difference was not statistically significant(P>0.05). The number of TPA and unstable plaques was significantly lower than that in the control group(P<0.05). Conclusion: Conventional treatment plus the Qima Huazhuo decoction can significantly reduce the level of serum inflammatory factors in patients with acute ischemic stroke, and reduce the degree of carotid atherosclerosis, for the recovery of neurological function and improvement of short-term prognosis in patients.

关 键 词：急性缺血性脑卒中 芪麻化浊汤 颈动脉粥样硬化斑块 炎症因子 

分 类 号：R255.2[医药卫生—中医内科学]