阿奇霉素注射剂与常用药物的配伍分析及其对策  

Compatibility Analysis on Azithromycin Injection with Common Drugs and Its Countermeasures

作　　者：李琴 王军兰 雷招宝 LI Qin;WANG Jun-Ian;LEI Zhao-bao(Department of Nursing, Guangzhou Modern Hospital, Guangzhou 510500, China;Department of Pharmacy, Guangzhou Chang'an Hospital, Guangzhou 510630, China)

机构地区：[1]广州现代医院护理部,广州51O5OO [2]广州长安医院药剂科,广州510630 [3]不详

出　　处：《抗感染药学》2019年第6期946-950,共5页Anti-infection Pharmacy

摘　　要：目的:分析阿奇霉素注射剂与常用药物的配伍及其对策,为护士配制与输注阿奇霉素注射剂时提供参考,保障患者用药安全。方法:检索国内医药数据库,下载有关阿奇霉素与其他药物配伍的相关文献,仔细阅读与分析,编制阿奇霉素注射剂配伍禁忌的目录。结果:阿奇霉素可与5%葡萄糖注射液、0.9%氯化钠注射液、5%葡萄糖氯化钠注射液、复方氯化钠注射液等临床常用输液剂配伍使用,与维生素C注射液、维生素B6注射液、利巴韦林注射液、山莨菪碱注射液等也可以配伍使用,但与中药注射剂(炎琥宁、痰热清等)、头孢菌素类抗生素(头孢匹胺、头孢尼西等)、氨溴索、更昔洛韦和呋塞米等药物有配伍禁忌。结论:为保障患者用药安全,避免不必要的药品浪费及用药的安全性,建议阿奇霉素注射剂单独静脉滴注,临床护士应重视阿奇霉素注射剂与其他药物配伍的禁忌问题。Objective: To analyze the compatibility of azithromycin injection with common drugs and its countermeasures and to provides a reference for nurses to prepare and inject azithromycin injection to ensure the safety of patients. Methods: The domestic medical database was searched and the related literatures about the compatibility of azithromycin with other drugs were downloaded, read and carefully analyzed, putting forward the list of the incompatibility of azithromycin injection. A list of contraindications of azithromycin injection were edited. Results: Azithromycin can be used together with 5% glucose injection, 0.9% sodium chloride injection, 5% glucose and 0.9% sodium chloride injection, compound sodium chloride injection and other commonly used clinical infusion solution. It can also be used in combination with vitamin C injection, vitamin B6 injection, ribavirin injection and anisodamine injection. However, compatibility with Traditional Chinese Medicine injections (Yanhuning injection, Tanreqing injection, etc.), cephalosporin antibiotics (cefopiamide, cefonicil, etc.), ambroxol, ganciclovir and fursamide is contraindicated. Conclusion: In order to ensure the safety of drug use, Unnecessary drug waste and safety danger of medication should be avoided;it is suggested that azithromycin injection should be injected by intravenous drip alone. Clinical nurses should pay attention to the contraindication of the compatibility of azithromycin injection with other drugs.

关 键 词：阿奇霉素 常用药物 配伍禁忌 用药安全 

分 类 号：R969.3[医药卫生—药理学]