中孕期孕妇21-三体高风险与胎儿产前超声软指标及其结构畸形的相关性  

Correlation between High Risk of 21-Trisomy and Fetus Antenatal Ultrasonography in Pregnant Woman of Middle Gestational Period

作　　者：杭桂芳 许豪勤 喻玲 高亚琴[3] 

机构地区：[1]南京中医药大学附属中西医结合医院超声诊断科,南京210028 [2]江苏省计划生育科学研究所,南京210036 [3]东南大学附属中大医院超声诊断科,南京210009

出　　处：《抗感染药学》2019年第6期991-994,共4页Anti-infection Pharmacy

基　　金：河南省医学科技攻关计划项目(编号:201403252)

摘　　要：目的:探究中孕期孕妇21-三体高风险与胎儿产前超声软指标及其结构畸形的相关性。方法:抽取2016年1月—2017年12月间中孕期唐氏综合征产前筛选(简称"唐筛")21-三体高风险孕妇289例资料为观察组,另抽取同时段中孕期唐筛21-三体低风险孕妇289例资料为对照组;比较和分析两组孕妇中孕期唐筛21-三体超声筛查结果以及胎儿的中孕期超声筛查声像特征。结果:观察组孕妇中,21-三体高风险与胎儿超声软指标和结构畸形的发生率分别为44.64%(129/289)和1.73%(5/298);对照组孕妇中,21-三体低风险与胎儿超声软指标和结构畸形的发生率分别为7.96%(23/289)和0.69%(2/289);对照组中孕期孕妇超声软指标的发生率显著低于观察组(P<0.05),而在结构畸形的发生率稍低于观察组,但经组间比较其差异有统计学意义(P<0.05)。结论:21-三体高风险中孕期孕妇胎儿超声软指标异常发生率明显高于21-三体低风险孕妇,21-三体高风险与胎儿超声软指标间具有相关性。Objective: To explore the correlation between the high risk of 21-trisomy (also known as Down's syndrome) and fetus antenatal ultrasonography results including abnormal soft indexes and structural malformation during the middle gestational period. Methods: The data of 289 cases of 21-trisomy high-risk pregnant women with Down's syndrome during the middle pregnancy admitted between January 2016 and December 2017 were selected as the observation group. In addition,the data of 289 cases of low-risk pregnant women with 21-trisomy were selected as the control group. The results of 21-trisomy ultrasound screening and the ultrasonographic characteristics of fetuses in the middle pregnancy of two groups were compared and analyzed. Results: Among the pregnant women in the observation group,the incidence of 21-trisomy high risk and fetal ultrasound soft index and structural malformation were 44.64%(129/289) and 1.73%(5/298),respectively. In the control group,the incidence of 21-trisomy low risk and fetal ultrasound soft index and structural malformation were 7.96%(23/289) and 0.69%(2/289),respectively. In the control group,the incidence of ultrasound soft index was significantly lower than that of the observation group (P<0.05),and the incidence of structural malformation was slightly lower than that of the observation group,but the difference was statistically significant (P<0.05). Conclusion: The incidence of abnormality of fetal ultrasonography in pregnant women with high risk of 21-trisomy was significantly higher than that in pregnant women with low risk of 21-trisomy, and there was a correlation between the high risk of trisomy 21-trisomy and fetal ultrasonography.

关 键 词：中孕期孕妇 胎儿产前 超声软指标 结构畸形 21-三体高风险 相关性 

分 类 号：R969.3[医药卫生—药理学]