与卡介苗接种相关的婴儿瘰疬性苔藓七例  

Seven cases of infant lichen scrofulosorum related to bacillus Calmette-Guérin vaccination

作　　者：林杨杨[1] 宫泽琨[1] 赵丽[1] 李钦峰[1] Lin Yangyang;Gong Zekun;Zhao Li;Li Qinfeng(Department of Dermatology,Tianjin Children′s Hospital,Tianjin 300134,China)

机构地区：[1]天津市儿童医院皮肤科,300134

出　　处：《中华皮肤科杂志》2019年第8期533-536,共4页Chinese Journal of Dermatology

摘　　要：目的探讨婴儿瘰疬性苔藓(LS)的病因、临床表现、诊断及转归特点。方法回顾2010—2018年在天津市儿童医院皮肤科门诊就诊的7例婴儿LS资料,分析其病因、临床特点及发展转归。结果7例婴儿LS均为卡介苗接种后出现,临床主要表现为分布于躯干的淡红色或淡褐色丘疹,表面附着细小鳞屑。实验室相关检查均未见异常,病理检查示真皮内肉芽肿改变。所有患儿皮疹未经治疗,且均在半年内消失,未遗留瘢痕或色素沉着。结论婴儿LS多出现在卡介苗接种后2~3个月,临床表现为多位于躯干的丘疹,病理表现为真皮内肉芽肿改变,皮损均可自愈。Objective To investigate the etiology, clinical manifestations, diagnosis and outcomes of lichen scrofulosorum (LS). Methods Clinical data collected from 7 infants with LS, who visited Department of Dermatology, Tianjin Children′s Hospital between 2010 and 2018, were analyzed retrospectively, and the etiology, clinical manifestations, diagnosis, development and outcomes of LS were investigated. Results All the 7 infants developed LS after bacillus Calmette-Guérin (BCG) vaccination, and the clinical manifestations of LS were reddish or hazel papules mainly distributed on the trunk with small scales attached to the surface. No abnormal laboratory examination results were observed. Histopathological examination showed granuloma in the dermis. Without any treatment, all rashes of the 7 patients disappeared within 6 months, and no scar or hyperpigmentation remained. Conclusions Infant LS usually appears 2-3 months after BCG vaccination, clinically presents as papules mostly on the trunk, pathologically characterized as granuloma in the dermis, and can heal spontaneously.

关 键 词：结核 皮肤 婴儿 皮肤表现 病理过程 瘰疬性苔藓 

分 类 号：R529.4[医药卫生—内科学]