不同间隔期、献血量对献血者血清铁和铁蛋白影响效果观察  

Effects of different amounts and intervals of blood donation on serum iron and ferritin of blood donors

作　　者：戚艳萍[1,2] 何博 黄晓斌[1,2] 苏玮 戴琳[1,2] 谢钊 QI Yanping;HE Bo;HUANG Xiaobing;SU Wei;DAI Lin;XIE Zhao(Guangzhou Blood Center, Guangzhou 510095, China;The Key Medical Laboratory of Guangzhou (the Key Laboratory of Blood Safety)

机构地区：[1]广州血液中心,广东广州510095 [2]广州市医学重点实验室(血液安全重点实验室)

出　　处：《中国输血杂志》2019年第6期570-572,共3页Chinese Journal of Blood Transfusion

摘　　要：目的探索不同间隔期、不同献血量定期献血对献血者血清铁蛋白和铁的影响效果。方法选自2015年3月-2018年3月于本中心的325例定期献血者作为研讨组,同时段内选取100例从未献血的正常体检人员作为参照组,分别测定血清铁蛋白与铁的水平,并进行观察对比。结果与参照组(无献血史)对比,不同的献血量的研讨400 mL组、300 mL组、200 mL组的血清铁水平相近,P>0.05;血清铁蛋白则差异显著(F=6.327,P<0.05);而且3个不同献血量研讨组之间,400 mL组与200 mL组差异明显(t=8.272,P<0.05)。不同间隔期献血者研究中,献3次(平均间隔期为12个月)、4次(平均间隔期为9个月)的献血者跟参照组(无献血史)比较,血清铁蛋白和血清铁结果无差异;献5次(平均间隔期为7.2个月)、6次(平均间隔期为6个月)跟参照组比较,血清铁差异不显著(P>0.05),但血清铁蛋白差异显著(5次vs.参照组:t=5.378,P<0.05;6次vs.参照组:t=6.894,P<0.05)。结论通过对不同献血量不同间隔期定期献血者与无献血史的正常体检人员的血清铁蛋白与铁的水平进行观察对比,献血200-400 mL,6个月<间隔期<9个月者血清铁蛋白减少,有利于身体健康。Objective To explore the effects of regular blood donation with different blood donation amounts on serum ferritin and iron in blood donors at different donation intervals.Methods 325 regular blood donorsin Guangzhou Blood Center from March 2015 to March 2018 were selected as the study group. At the same time, 100 normal physical examinees who had never donated blood were selected as the reference groups to determine the levels of serum ferritin and iron. Protein and iron levels of two groups were compared and observed. Results Compared with the reference group(without any history of blood donation), significant difference was observed in serum ferritin(F=6.327, P<0.05) but not in serum iron levels(P>0.05) among donors with 400, 300 and 200 mL donation;the differences between 400 and 200 mL donation were significant(t=8.272, P<0.05). In the study of blood donation at different intervals, no significant difference was observed in the results of serum ferritin and serum iron of blood donors who had donated 3 times(at an average interval of 12 months) and 4 times(at an average interval of 9 months) compared with the reference group;significant difference was observed in serum ferritin but not in serum iron levels of blood donors who had donated 5 times(at an average interval of 7.2 months)(t=5.378,P<0.05) and 6 times(at an average interval of 6 months)(t=6.894,P<0.05) compared with the reference group. Conclusion Through the observation and comparison of the serum ferritin and iron levels between regular blood donors with different intervals and amounts of blood donation and normal physical examinees with no blood donation history,,a conclusion can be drawn that blood donation within 200-400 mL and interval within 6 and 12 months are good for healthy.

关 键 词：不同间隔期 不同献血量 血清铁蛋白 铁 

分 类 号：R193.3[医药卫生—卫生事业管理]