孕妇孕期血小板抗体检测的影响因素分析  

Analysis of the influencing factors of the detection of platelet antibodies in 1317 pregnant women during pregnancy

作　　者：陈丽 周浩[1] 郭博[1] 管政[1] 吴静[1] 张军[1] CHEN Li;ZHOU Hao;GUO Bo;GUAN Zheng;WU Jing;ZHANG Jun(Department of Blood Transfusion, First affiliated Hospital of Bengbu Medical College, Bertgbu 233000, China)

机构地区：[1]蚌埠医学院第一附属医院输血科

出　　处：《中国输血杂志》2019年第6期575-577,共3页Chinese Journal of Blood Transfusion

摘　　要：目的研究孕12周以后孕妇血小板抗体的阳性率,并对其影响因素进行分析。方法对2016年12月-2018年7月本院门诊产检的1317例孕12周以后的孕妇,采用红细胞固相凝集法进行血小板抗体的筛查,对可能影响血小板抗体阳性的因素进行单因素分析,并按照孕妇年龄、孕周、孕次做多因素分组,采用Logistic回归分析方法比较各因素与血小板抗体阳性之间的相关性。结果 1317例孕妇中,血小板抗体阳性68例,阳性率为5.2%;单因素结果分析显示:孕次、孕周是孕妇血小板抗体阳性率的影响因素(P<0.05);多因素logistic回归分析显示孕次、孕周是对孕妇血小板抗体阳性率有影响的独立危险因素,差异有统计学意义(P<0.05)。结论妊娠次数、孕周与血小板抗体阳性率密切相关,对有多次妊娠史的经产妇进行相应孕期血小板抗体的筛查,在预防流产、新生儿同种免疫性血小板减少性紫癜(NAITP)等方面具有重要的临床意义。Objective To investigate the positive rate of platelet antibodies in pregnant women with gestational age over 12 weeks and to analyze the influencing factors. Methods From December 2016 to July 2018, 1317 pregnant women with gestational age over 12 weeks were screened for platelet antibodies by erythrocyte solid phase agglutination method. Univariate analysis was performed on the factors that may affect the positive rate of platelet antibody, and then multivariate analysis was performed according to the age, gestational week and numbers of pregnancy. Logistic regression analysis was used to compare the correlations between each factor and the positive rate of platelet antibody.Results A total of 68 patients with positive platelet antibodies were screened out in 1317 pregnant women, and the positive rate was 5.2%. The results of univariate analysis showed that the number of pregnancies and gestational week were the influencing factors of the positive rate of platelet antibody(P<0.05). The results of logistic regression analysis showed that the number of pregnancies and gestational week were independent risk factors for the positive rate of platelet antibody, and the differences were statistically significant(P<0.05). Conclusion The number of pregnancies and gestational week are closely related to the positive rate of platelet antibodies. Screening for platelet antibodies at suitable time in pregnant women with history of multiple pregnancies has important significance in preventing abortion and neonatal alloimmune thrombocytopenic purpura(NAITP).

关 键 词：血小板抗体 妊娠次数 孕周 

分 类 号：R714.1[医药卫生—妇产科学]