胰肾联合移植后移植胰腺存活18年一例及文献复习  

A case report of transplanted pancreas survival longer than 18 years after simultaneous pancreas-kidney transplantation and literature review

作　　者：卢峡[1] 宫念樵[1] 曾凡军[1] 陈忠华 陈知水[1] 明长生[1] Lu Xia;Gong Nianqiao;Zeng Fanjun;Chen Zhonghua;Chen Zhishui;Ming Changsheng(Institute of Organ Transplantation, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Key Laboratory of Organ Transplantation, Ministry of Education,NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China)

机构地区：[1]华中科技大学同济医学院附属同济医院器官移植研究所,教育部器官移植重点实验室,国家卫生健康委员会器官移植重点实验室,中国医学科学院器官移植重点实验室,武汉430030

出　　处：《中华器官移植杂志》2019年第5期277-279,共3页Chinese Journal of Organ Transplantation

基　　金：国家高技术研究发展计划(863计划)子项目(2012AA021010);中国医学科学院中央级公益性科研院所基本科研业务费专项资金资助(2018PT32018).

摘　　要：目的探讨胰肾联合移植(SPK)术后长期存活的影响因素及治疗策略。方法回顾1例SPK术后长期存活的病例,结合其病例特点和相关文献,分析SPK受者长期存活的影响因素。结果受者SPK术后10年因排斥反应出现移植肾功能丧失,行再次肾移植,至今肾功能良好;移植胰腺功能良好,存活至今超过18年。结论严格术前筛查,采用成熟的手术术式,积极防治移植围手术期各种并发症,加强受者健康教育、提高依从性,长期规律的随访,有利于提高SPK术后受者和移植物的长期存活。Objective To explore the influencing factors and treatment strategies of long-term survival after simultaneous pancreas and kidney transplantation (SPK). Methods One case of long-term post-SPK survival was reviewed and its influencing factors were analyzed along with the relevant literature. Results At 10 years post-SPK, the patient lost transplanted kidney due to rejection and underwent secondary kidney transplantation. The transplanted pancreas functioned well and has survived for more than 18 years. Conclusions Strict preoperative screening, adopting mature surgical approaches, aggressive managements of various perioperative complications, strengthening of health education of recipients, improving of compliance and long-term regular follow-ups are conducive for enhancing long-term survival of recipients and grafts of SPK.

关 键 词：胰肾联合移植 糖尿病肾病 排斥反应 规律随访 

分 类 号：R699.2[医药卫生—泌尿科学] R657.5[医药卫生—外科学]