阿仑膦酸钠干预人工关节置换术后假体周围骨质疏松临床应用研究  

Resarch on the Clinical Application of Alendronate Sodium in the Treatment of Periprosthetic Osteoporosis After Artificial Joint Replacement

作　　者：胡杰亮[1] 高富军[1] 周保军[1] 吴萍[1] 魏孔星 吕利军 李文涛 HU Jie-liang;GAO Fu-jun;ZHOU Bao-jun(The First People’s Hospital of Baiyin,Baiyin,Gansu,730900,China)

机构地区：[1]甘肃省白银市第一人民医院

出　　处：《中国初级卫生保健》2019年第8期97-99,共3页Chinese Primary Health Care

基　　金：白银市科技计划资助项目(2017-2-31Y)

摘　　要：目的探讨阿仑膦酸钠对于预防关节置换术后假体周围骨质疏松的作用。方法采用随机数字表法选择人工关节置换术后患者,分为治疗组和对照组,每组各25例,治疗组在术后3天度过围手术期后开始口服阿伦膦酸钠,70 mg/w,持续服药1年。对照组同期口服骨化三醇0.25μg,2次/d,持续1年。在术后的3个月、6个月、12个月、18个月和24个月为患者行骨密度仪检测,并检测患者的NTX-Ⅰ和BAP。结果治疗组患者骨密度在术后2年内的各时间点检测均高于对照组,结果具有统计学差异。同时,治疗组患者的BAP和NTX-Ⅰ水平也低于对照组,结果具有统计学差异。结论阿仑膦酸钠持续服用1年对预防人工关节置换术后假体周围骨质疏松具有明确的临床意义。OBJECTIVE To investigate the effect of alendronate on prevention of osteoporosis around the prosthesis after joint replacement.METHODS The patients were randomly divided into alendronate treatment group(group A)and oral calcitriol control group(group B),with 25 cases in each group. In group A,alendronate was treated on the 3 rd postoperative day,70 mg/week,for 1 year. In group B,0.25μg of calcitriol was orally administered twice a day for 1 year. The patients were tested for bone densitometry in 3 months,6 months,12 months,18 months,24 months and the patients’ NTX-I and BAP were detected. RESULTS Bone mineral density in group A was higher than that in group B within 2 years after surgery. The results were statistically significant. At the same time,the BAP and NTX-I levels of patients in group A were also lower than group B,and the results were statistically different. CONCLUSION Treatment with alendronate for1 year after surgery had a clear clinical significance in preventing osteoporosis around the prosthesis after artificial joint replacement.

关 键 词：假体周围骨质疏松 人工关节置换 阿仑膦酸钠 

分 类 号：R687.4[医药卫生—骨科学]