病毒致出生缺陷或不良妊娠结局研究进展  

Research Progress on Birth Defects or Adverse Pregnancy Outcomes Caused by Viruses

作　　者：刘扬 新燕[1] 田婵 LIU Yang;XIN Yan;TIAN Chan(College of Basic Medicine, Inner Mongolia Medical University, Hohhot 010110, China;Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology, Key Laboratory of Assisted Reproduction( Peking University), Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China)

机构地区：[1]内蒙古医科大学基础医学院,呼和浩特010110 [2]北京大学第三医院妇产科生殖医学中心,国家妇产疾病临床医学研究中心,辅助生殖教育部重点实验室(北京大学),北京市生殖内分泌与辅助生殖技术重点实验室,北京100191

出　　处：《病毒学报》2019年第4期662-671,共10页Chinese Journal of Virology

基　　金：国家重点研发计划(项目号:2016YFC1000501);题目:环境因素导致重要器官发育异常的关键环节~~

摘　　要：出生缺陷是全社会关注的问题,是提高国民健康素质的重要一环,已有一些致病的遗传、环境因素被揭示,但是仍有相当一部分出生缺陷原因不明。孕期病毒感染可导致出生缺陷或不良妊娠结局,如风疹病毒、巨细胞病毒、单纯疱疹病毒、人类细小病毒B19等。近年来,随着新发突发传染病的出现,致畸病毒谱也在不断扩大,如孕期寨卡病毒感染可导致胎儿小头畸形。不同病毒在孕期的致畸概率存在一定的差异,致畸机制也不尽相同,了解这些病毒的致畸机制,提早诊断并采取相应救治措施,不仅可以减少患者及家属的伤害,也可以预防出生缺陷,减轻社会负担。本文对一些常见的可致畸病毒及作用机制进行综述。Birth defects are public health problems. Though most birth defects are associated with genetic or environmental factors,a proportion are agnogenic. Virus infection during pregnancy may cause birth defects or adverse pregnant outcomes. Infection with the rubella virus,cytomegalovirus,herpes simplex virus,or human parvovirus B19 can lead to birth defects. In recent years,as more infectious diseases have emerged,teratogenic viruses have been identified. For instance,infection with the Zika virus during pregnancy can cause fetal microcephaly. The probability of infection and mechanism of action of individual teratogenic viruses is different.Understanding the mechanism of action of teratogenic viruses,and diagnosing and treating infection as soon as possible,can increase survival chances and decrease the burden on healthcare systems. Here,we review the common teratogenic viruses and their mechanisms of action.

关 键 词：出生缺陷 致畸病毒 不良妊娠结局 机制 

分 类 号：R373.9[医药卫生—病原生物学] R511[医药卫生—基础医学]