趋化因子IP-10在介导病毒感染性疾病中的研究进展  

Research Progress in IP-10-mediated Inflammation in Viral Infectious Diseases

作　　者：胡艮娣 王晓泉 陈祥 张评浒 HU Gendi;WANG Xiaoquan;CHEN Xiang;ZHANG Pinghu(Jiangsu Key Laboratory of New Drug Screening, China Pharmaceutical University, Nanjing 210009, China;Key Laboratory of Animaland Poultry Infectious Diseases, Ministry of Agriculture, Yangzhou University, Yangzhou 225009, China;Jiangsu Key Laboratory ofZoonosis, Yangzhou University, Yangzhou 225009, China;Institute of Translational Medicine, Key Laboratory of Geriatric Disease Prevention and Control of Jiangsu Province, Medical College, Yangzhou University, Yangzhou 225009, China)

机构地区：[1]江苏省新药筛选重点实验室,中国药科大学,南京210009 [2]农业部畜禽传染病学重点开放实验室,扬州大学,扬州225009 [3]江苏省人兽共患病重点实验室,扬州大学,扬州225009 [4]转化医学研究院江苏省中西医结合老年病防治重点实验室,扬州大学医学院,扬州225009

出　　处：《病毒学报》2019年第4期672-678,共7页Chinese Journal of Virology

基　　金：江苏省人兽共患病学重点实验室开放课题(项目号:R1707),题目:靶向IP-10的新型抗H7N9禽流感病毒药物筛选体系的建立;青海省高端创新人才项目~~

摘　　要：干扰素诱生蛋白10(Interferon-inducible protein-10,IP-10)是由IFN-γ诱导产生的一个分子量为10kD的趋化因子,通过与受体CXCR3作用,发挥趋化作用与多种生物学功能。IP-10作为Th1型促炎趋化因子,招募多种细胞到达炎症部位,在炎症中发挥作用。同时IP-10在包括危害人类较大的病毒性疾病如乙型肝炎病毒(Hepatitis B virus,HBV)、人类免疫缺陷病毒(Human immunodeficiency virus,HIV)、H7N9禽流感病毒、呼吸道合胞病毒(Respiratory syncytial virus,RSV)等感染所致的炎症中也发挥重要作用。本研究就IP-10与病毒感染性疾病中炎症产生的密切关系作一综述,以供同行参考。Interferon-inducible protein-10(IP-10)is a chemokine induced by IFN-γ with a molecular weight of10 kD. It exerts chemotaxis and multiple biological functions through interaction with its only receptor:C-X-C motif receptor 3(CXCR3). IP-10 is a T-helper type-1 pro-inflammatory chemokine,and recruits various cells to reach the site of inflammation. IP-10 and its receptor CXCR3 play important roles in the inflammation wrought by viral infectious diseases,including those caused by the hepatitis-B virus,human immunodeficiency virus,Asian lineage avian influenza A virus,and respiratory syncytial virus.This article reviewed the role of IP-10 in viral infectious diseases and provided a reference for the colleagues.

关 键 词：干扰素诱生蛋白10(IP-10) 乙型肝炎病毒(HBV) 人类免疫缺陷病毒(HIV) H7N9 炎症 

分 类 号：R392.5[医药卫生—免疫学] R511[医药卫生—基础医学]