野八角果实化学成分的研究  

Chemical constituents from the fruits of Iliicium simonsii

作　　者：王晓霞 庄鹏宇 苟丽霞 李雪琴 WANG Xiao-xia;ZHUANG Peng-yu;GOU Li-xia;LI Xue-qin(School of Pharmacy,North China University of Science and Technology,Tangshan 063210,China;School of Life Sciences,North China University of Science and Technology,Tangshan 063210,China)

机构地区：[1]华北理工大学药学院,河北唐山063210 [2]华北理工大学生命科学院,河北唐山063210

出　　处：《中成药》2019年第8期1867-1871,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学青年基金(31700083);河北省自然科学基金(H2015209094,H2014209241)

摘　　要：目的野八角Iliicium simonsii Maxim果实化学成分的研究。方法野八角果实95%乙醇提取物的甲醇部位采用大孔树脂、硅胶、Sephadex LH-20、ODS、半制备反相HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到9个化合物,分别鉴定为illioliganone C (1)、4(R)-allyl-4-(3-methylbut-2-enyl)-1, 2-methylenedioxy-cyclohexa-2, 6-dien-5-one (2)、3-hydroxyillifunone B (3)、illifunpyranone (4)、1β, 4β, 7α-trihydroxyeudesmane (5)、pseudoanisatin (6)、tashironin (7)、8′-oxo-6-hydroxy-dihydrophaseic acid (8)、henrylactone D (9)。结论所有化合物均为首次从该植物中分离得到,化合物8~9为首次从该属植物中分离得到。AIM To study the chemical constituents from the fruits of Iliicium simonsii Maxim. METHODS The methanol fraction of 95% ethanol extract from I. simonsii was isolated and purified by macroporous resin,silica gel,Sephadex LH-20,ODS and semipreparative reversed-phase HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data. RESULTS Nine compounds were isolated and identified as illioliganone C ( 1),4 ( R)-allyl-4-( 3-methylbut-2-enyl)-1,2-methylenedioxy-cyclohexa-2,6- dien-5-one ( 2),3-hydroxyillifunone B ( 3),illifunpyranone ( 4),1β,4β,7α-trihydroxyeudesmane ( 5), pseudoanisatin ( 6 ), tashironin ( 7 ), 8'-oxo-6-hydroxy-dihydrophaseic acid ( 8 ), henrylactone D ( 9 ). CONCLUSION All the compounds are isolated from this plant for the first time,and compounds 8 - 9 are isolated from genus Iliicium for the first time.

关 键 词：野八角 果实 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]