铁牛七化学成分的研究  

Chemical constituents from Aconitum szechenyianum

作　　者：宋蓓[1,2] 王菲 李玉泽[2] 张化为[4] 黄文丽 李翠 宋小妹[4] 刘建利[2] SONG Bei;WANG Fei;LI Yu-ze;ZHANG Hua-wei;HUANG Wen-li;LI Cui;SONG Xiao-mei;LIU Jian-li(The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712046,China;The College of Life Sciences,Northwest University,Xi’an 710069,China;Shaanxi Institute for Food and Drug Control,Xi’an 710065,China;School of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学第二附属医院,陕西咸阳712046 [2]西北大学生命科学院,陕西西安710069 [3]陕西省食品药品监督检验研究院,陕西西安710065 [4]陕西中医药大学药学院,陕西咸阳712046

出　　处：《中成药》2019年第8期1871-1875,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金资助项目(81102805,81373978);陕西省教育厅资助项目(15JK1204);陕西中医药大学学科创新团队项目(2019-YL12)

摘　　要：目的研究铁牛七Aconitum szechenyianum Gay.的化学成分。方法铁牛七80%乙醇提取物采用正相硅胶、半制备高效液相色谱柱进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到7个化合物,分别鉴定为8-O-methylaconine(1)、8-O-ethyl-aconine(2)、8-O-ethyl-14-benzoylmesaconine(3)、苯甲酰乌头原碱(4)、N-甲基苯甲酰胺(5)、β-谷甾醇(6)、棕榈酸(7)。结论化合物1~4为首次从该植物中分离得到。AIM To study the chemical constituents from Aconitum szechenyianum Gay.. METHODS The 80% ethanol extract from A. szechenyianum was isolated and purified by silica and semi-preparative HPLC column, then the structures of obtained compounds were identified by physicochemical properties and spectral data. RESULTS Seven compounds were isolated and identified as 8-O-methylaconine ( 1),8-O-ethylaconine ( 2),8- O-ethyl-14-benzoylmesaconine ( 3),benzoylaconine ( 4),N-methyl benzamide ( 5),β-sitosterol ( 6),palmitic acid ( 7). CONCLUSION Compounds 1-4 are isolated from this plant for the first time.

关 键 词：铁牛七 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]