从肝论治法治疗复发/难治性免疫性血小板减少症对患者T淋巴细胞亚群的影响  

Effect of Treatment by Regulating Liver on T Lymphocyte Subsets in Patients with Refractory/Relapsed Immune Thrombocytopenia

作　　者：杨淑莲 刘希赞 孟予城 YANG Shu-lian;LIU Xi-zan;MENG Yu-cheng(Langfang Traditional Chinese Medicine Hospital,Langfang,Hebei 065000,China)

机构地区：[1]廊坊市中医医院

出　　处：《河北北方学院学报（自然科学版）》2019年第8期11-13,16,共4页Journal of Hebei North University:Natural Science Edition

基　　金：河北省中医药管理局中医药类科研计划(No.2015067)

摘　　要：目的 探讨从肝论治法治疗复发/难治性免疫性血小板减少症(immune thrombocytopenia,ITP)对患者外周血T淋巴细胞亚群的影响。方法 复发/难治性ITP门诊患者36例为治疗前组,完成从肝论治法治疗2.5个月的复发/难治性ITP患者11例为治疗后组,健康体检者34例为对照组;利用流式细胞术检测治疗前组、治疗后组、对照组外周血T淋巴细胞亚群(CD3^+CD4^+、CD3^+CD8^+)水平。结果 复发/难治性ITP治疗前组CD3^+CD4^+T淋巴细胞比例较低,CD3^+CD8^+T淋巴细胞比例较高,与对照组比较差异有统计学意义( P <0.05)。治疗后组CD3^+CD4^+T淋巴细胞比例升高,与对照组比较差异无显著性( P >0.05),CD3^+CD8^+T淋巴细胞比例降低,与对照组比较差异有显著性( P <0.05)。治疗组内比较,治疗后与治疗前相比,CD3^+CD4^+T淋巴细胞比例升高,CD3^+CD8^+T淋巴细胞比例降低,差异有统计学意义( P <0.05)。结论 复发/难治性ITP患者外周血T淋巴细胞亚群水平存在异常,从肝论治法治疗复发/难治性ITP对患者外周血T淋巴细胞亚群具有调节作用。Objective To explore the effect of treatment by regulating liver on T lymphocyte subsets of peripheral blood in patients with refractory/relapsed immune thrombocytopenia(ITP). Methods 36 outpatients with refractory/relapsed ITP were in the pre-treatment group,11 patients with refractory/relapsed ITP after 2.5 months of treatment by regulating liver were in the post-treatment group,and 34 healthy persons were in the control group.T lymphocyte subsets(CD3^+CD4^+,CD3^+CD8^+)of peripheral blood in the pre-treatment group,the post-treatment group and the control group were detected by flow cytometry. Results The percentage of CD3^+CD4^+ T lymphocyte was lower and that of CD3^+CD8^+ T lymphocyte was higher in the pre-treatment group,there were significant differences compared with the control group (P <0.05).The percentage of CD3^+CD4^+ T lymphocyte in the post-treatment group was higher,there were no significant differences compared with the control group (P >0.05);while the percentage of CD3^+ CD8^+ T lymphocyte in the post-treatment group was lower,there were significant differences compared with the control group (P <0.05).In the treatment group,the percentage of CD3^+CD4^+ T lymphocyte increased and that of CD3^+CD8^+ T lymphocyte decreased after treatment,there were significant differences compared with the pre-treatment group (P <0.05). Conclusion There is an abnormality of T lymphocyte subsets of peripheral blood in patients with refractory/relapsed immune thrombocytopenia.Treatment by regulating liver can regulate T lymphocyte subsets of peripheral blood in patients with refractory/relapsed immune thrombocytopenia.

关 键 词：复发/难治性ITP 从肝论治 T细胞亚群 

分 类 号：R5582[医药卫生—血液循环系统疾病]