光动力诊疗中的5-氨基酮戊酸及酯类衍生物的研究进展  

Research Progress of 5-Aminolevulinic Acid and Its Esters in Photodynamic Diagnosis and Therapy

作　　者：蒋捷 邹健 朱杏楣 胡永基 李伟军 黄正 JIANG Jie;ZOU Jian;Ellie S. M. Chu;Ricky W. K.Wu;LI Weijun;HUANG Zheng(Fujian Normal University, Key Laboratory of OptoElectronic Science and Technology for Medicine of Minister of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fuzhou 350007, China;Tung Wah College, School of Medical and Health Sciences, Hong Kong 999077, China)

机构地区：[1]福建师范大学光电与信息工程学院,医学光电科学与技术教育部重点实验室,福建省光子技术重点实验室,福州350007 [2]东华学院医疗及健康科学学院,香港999077

出　　处：《激光生物学报》2019年第4期289-295,共7页Acta Laser Biology Sinica

基　　金：国家自然科学基金项目(81471703);中央引导地方科技发展专项项目(2017L3009)

摘　　要：5-氨基酮戊酸(ALA)是体表光动力疗法的一个重要前体药物,通过代谢产物原卟啉Ⅸ(PpⅨ)介导发挥光敏作用。ALA制剂的研发和优化促生了一系列产品和技术,不仅推动了体表光动力疗法的应用,而且ALA介导的PpⅨ荧光还可用于肿瘤的荧光可视化和辅助手术。本文将对光动力诊疗中ALA及其酯类衍生物和PpⅨ的研究进展作一个系统介绍。5-Aminolevulinic acid (ALA) is an important prodrug in topical photodynamic therapy (PDT). Its photosensitization is mediated through protoporphyrin Ⅸ(PpⅨ). The ALA-related drug development and application optimization promote a series of products and techniques that expanded the clinical applications of topical PDT. PpⅨ fluorescence visualization not only plays an important role in topical PDT, it is also useful in fluorescence-guided surgery for bladder cancer and gliomas. This review will provide an overview on some progress in ALA, ALA esters and PpⅨ applications.

关 键 词：5-氨基酮戊酸 酯类衍生物 PpⅨ 光动力诊断 光动力治疗 

分 类 号：R454.2[医药卫生—治疗学]