长沙市2889例3月～16岁儿童幽门螺旋杆菌感染现状及对生长发育的影响分析  

Present Situation of Helicobacter pylori Infection and Its Influence on Growth and Development in Aged 3 months～16 years 2 889 Children in Changsha

作　　者：戴红梅[1] 赵玲玲[1] 李颖[1] 田朗[1] 陈志衡[1] DAI Hongmei;ZHAO Lingling;LI Ying;TIAN Lang;CHEN Zhiheng(Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, 410013, China)

机构地区：[1]中南大学湘雅三医院儿科

出　　处：《激光生物学报》2019年第4期380-384,F0003,共6页Acta Laser Biology Sinica

基　　金：湖南省哲学社会科学基金项目(16YBQ073)

摘　　要：本研究对长沙市2889名3月~16岁无症状体检儿童进行了生长发育评估,并通过胶体金法检测了其血清幽门螺旋杆菌(Helicobacter pylori)IgG水平。结果显示共检测的2889名儿童(男童1652名,女童1237名)中幽门螺旋杆菌感染阳性765名(26.4%),男童432名(26.2%),女童333(26.9%)。各年龄组幽门螺旋杆菌感染率分别为3月~1岁为31.8%、1岁~3岁为31.4%、3岁~6岁为18.9%、6岁以上15.4%。采用卡方检验及非参数检验进行统计,结果显示男女两组儿童幽门螺旋杆菌感染率无统计学差异(P>0.05)。3月~1岁与1岁~3岁、3岁~6岁与6岁以上组间幽门螺旋杆菌感染率无差异,其余组两两间均有差异。幽门螺旋杆菌感染阴性组儿童的身长/身高与幽门螺旋杆菌感染阳性组间无统计学差异(P>0.05),而幽门螺旋杆菌感染阴性组儿童的体重与幽门螺旋杆菌感染阳性组间有统计学差异(P<0.001);幽门螺旋杆菌感染阳性组与幽门螺旋杆菌感染阴性组中营养不良或矮身材发生率不具有统计学差异(P>0.05)。结果表明,幽门螺旋杆菌的感染在儿童群体中并无性别差异,并未使儿童的身材/身高、以及矮身材、营养不良等严重生长发育性疾病的发病率增加,但可能对儿童的体重带来一定影响。Growth and development were assessed in 2 889 children aged 3 months ~16 years who underwent physical examination without symptoms in Changsha. Serum Helicobacter pylori ( H.pylori ) IgG was detected by colloidal gold method. The results showed that a total of 2 889 children, 1 652 boys and 1 237 girls, were tested, among which 765 (26.4%) were positive for H.pylori infection, including 432 (26.2%) boys and 333 (26.9%) girls. The prevalence rate of H.pylori in all age groups was 31.8% at the age of 3 months ~1 years old, 31.4% at the age of 1 ~3 years old, 18.9% at the age of 3 ~6 years old, and 15.4% above the age of 6 years old, respectively. Chi-square test and non- parametric test were used. There was no significant difference in H.pylori infection rate between the two groups of different genders ( P> 0.05). There was no difference in the infection rate of H.pylori between group 3 months ~1 years old and group 1 to 3 years old, and between group 3 to 6 years old and group above 6 years old. Conversely, there was significant difference between the other two groups. There was no difference between the H.pylori positive and H.pylori negative groups in the body length or height ( P> 0.05).Nevertheless, the weights of the children in the H.pylori negative group were higher than those in the H.pylori positive group ( P <0.001). There was also no difference in the incidence of malnutrition between the H.pylori positive and H.pylori negative groups, nor in the incidence of short stature ( P> 0.05). This indicates that there is no difference in the infection of H.pylori in different genders. The infection of H.pylori in children does not increase the incidence of severe growth disorders such as short stature and malnutrition, however, it still exerts certain levels of influence on the growth and development of children ’s body length/height and weight.

关 键 词：幽门螺旋杆菌 儿童 生长发育 营养不良 矮身材 

分 类 号：R173[医药卫生—妇幼卫生保健]