含麻黄中成药用药规律分析  

Analysis of prescription rules of Chinese medicine containing ephedra

作　　者：高越[1] 黄正德[1] 刘施 李悦 孙婉瑾[1] 胡晓雪[1] GAO Yue;HUANG Zhengde;LIU Shi;LI Yue;SUN Wanjin;HU Xiaoxue(Department of Pharmaceutical Affairs,Hubei Provincial Hospital of TCM,Hubei Province,Wuhan 430061,China)

机构地区：[1]湖北省中医院药事部

出　　处：《中国医药导报》2019年第22期126-130,共5页China Medical Herald

基　　金：国家中医药管理局中药炮制技术传承基地建设项目(鄂财社发[2015]68号)

摘　　要：目的分析含麻黄中成药组方规律,为临床合理使用中药及新药前期研究提供参考。方法运用中医传承辅助平台(V2.5)软件,对《中药成方制剂》中含麻黄方剂进行收集并整理,构建相关数据库。采用关联规则、频次统计等数据挖掘方法,对疾病证候、常用药物配伍及组方规律进行分析,并对高频药对和高频证候进行深度分析。结果含麻黄方剂共284首,涉及中药589味。常用药物组合28个,主治疾病有9种,对3种高频疾病“咳嗽”“痹病”“哮病”进行药物组合分析,麻黄在不同组合药对中发挥作用相似,均有辛散温通的作用。结论《中药成方制剂》中含麻黄方剂多具有化痰、止咳、祛风解表之功,用药较为集中,组方清晰;用药规律反映麻黄治疗不同疾病时配伍的特点,可为充分发挥麻黄方的功效以及临床科学处方提供依据。Objective To analyze the prescription rules of Chinese patent medicine containing ephedra,and provide reference for the clinical use of traditional Chinese medicine and preliminary research of new drug.Methods Using traditional Chinese medicine inheritance support system (V2.5) software,the ephedrine formula contained in the Chinese Medicine Formulation of Set Prescription was collected and sorted to construct a related database.Using data mining methods,such as association rules and frequency statistics,the disease syndrome,common drug compatibility and prescription rules were analyzed,and the high frequency drug compositions and high frequency syndromes were analyzed in depth.Results There were 284 prescriptions containing ephedra,involving 589 flavors of traditional Chinese medicine.There were 28 commonly used drug compositions,9 kinds of main diseases.The drug compositions of three high-frequency diseases such as “cough”,“caries” and “shrub” were analyzed.Ephedra plays a similar role in different drug compositions,all had the effect of pungent divergence and warmly dredging.Conclusion Most of the prescriptions containing ephedra in Chinese Medicine Formulation of Set Prescription have the effects of dissipating phlegm,relieving cough and dispelling pathogenic wind for relieving superficies syndrome.The medication is more concentrated and the prescription is clear.The rule of medication reflects the compatibility of ephedra in the treatment of different diseases,which can provide a basis for fully utilizing the efficacy of ephedra prescription and clinical scientific prescription.

关 键 词：麻黄 中药成方制剂 中医传承辅助系统 组方规律 

分 类 号：R284.2[医药卫生—中药学]