脐带血IRAK-M基因多态性与新生儿早产及主要并发症的关系  

Relationship between polymorphism of cord blood IRAK-M gene and premature neonate as well as major complications

作　　者：黄君 王丽珍[1] HUANG Jun;WANG Lizhen(Department of Neonatology, Taizhou Hospital in Zhejiang Province, Linhai 317000, China)

机构地区：[1]浙江省台州医院新生儿科

出　　处：《中国现代医生》2019年第20期19-22,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划(2015KYA238)

摘　　要：目的探讨脐带血白细胞介素1受体相关激酶-M(interleukin-1 receptor-associatd kinase-M,IRAK-M)基因多态性与新生儿早产及主要并发症的关系。方法选择2015年1月~2017年12月本院出生的≤34周的早产儿200例为研究对象,母亲分娩时取脐带血,测定IRAK-M基因位点多态性;记录早产儿的临床资料,分析IRAK-M基因多态性与早产儿主要并发症的关系。结果 200例早产儿中主要住院情况有创机械通气治疗、吸氧治疗、肺表面活性物质应用、低血压或休克、败血症、发生呼吸暂停。早产儿的IRAK1主要基因分型为rs3027898 (CC、AC或AA3种基因型)和rs1059703(CC、CT或TT3种基因型)。rs3027898 (AC+AA)和rs1059703 (CT+TT)增加了RDS的发生率,rs3027898(AC+AA)增加了ROP发生率,差异有统计学意义(P<0.05)。结论测定脐带血IRAK-M基因多态性可以影响早产儿的主要并发症,有助于评估患儿预后。Objective To investigate the relationship between polymorphism of interleukin-1 receptor-associative kinase-M(IRAK-M) gene and premature delivery as well as major complications in neonates.Methods A total of 200 premature infants(≤34 weeks) born in our hospital from January 2015 to December 2017 were enrolled. The cord blood was taken when the mother gave birth. And the IRAK-M locus polymorphism was determined. The clinical data of premature infants were recorded and the relationship between IRAK-M gene polymorphism and major complications in preterm infants was analyzed. Results The main hospitalizations in 200 preterm infants were invasive mechanical ventilation, oxygen therapy,pulmonary surfactant application, hypotension or shock, sepsis, and apnea. The main genotype of IRAK1 in premature infants is rs3027898(CC, AC or AA genotypes) and rs1059703(CC, CT or TT3 genotypes).rs3027898(AC+AA) and rs1059703(CT+TT) increased the incidence of RDS, and rs3027898(AC AA) increased the incidence of ROP, and the difference was statistically significant(P<0.05). Conclusion Measuring IRAK-M gene polymorphism in cord blood can affect the main complications of premature infants and help to assess the prognosis of children.

关 键 词：白细胞介素1受体相关激酶-M 多态性 早产 脐带血 

分 类 号：R722.6[医药卫生—儿科]