不同剂量抗菌药物对肝硬化消化道出血患者医院感染及再出血的影响分析  

Effects of different doses of antibiotics on nosocomial infection and rebleeding in patients with digestive tract hemorrhage due to cirrhosis

作　　者：赵玉芹[1] 潘素荣[2] 王琮[2] 张芳[2] 刘宝珍[2] Zhao Yuqin;Pan Surong;Wang Cong;Zhang Fang;Liu Baozhen(Department of Emergency,Binzhou People's Hospital,Binzhou,Shandong 256610, China;Department of Gastroenterology,Binzhou People's Hospital,Binzhou,Shandong 256610,China)

机构地区：[1]滨州市人民医院急诊科,山东滨州256610 [2]滨州市人民医院消化内科,山东滨州256610

出　　处：《医药前沿》2019年第19期23-24,共2页Journal of Frontiers of Medicine

摘　　要：目的:探讨应用不同剂量的抗菌药物对肝硬化合并食管胃底静脉曲张破裂出血患者进行预防性抗感染治疗的效果.方法:选取200例肝硬化并伴有食管胃底静脉曲张破裂出血的患者作为研究对象,随机将患者分成A、B、C、D、E组各40例.分别给予不同剂量、种类抗菌药物后比较各组患者的医院感染率、再出血率及住院病死率.结果:A组患者与B组患者、C组与D组患者的医院感染率、再出血率相比较,差异无统计学意义(P>0.05),但均低于E组(P<0.05),而5组患者的住院病死率的差异无统计学意义.结论:肝硬化并伴有食管胃底静脉曲张破裂出血者中预防性使用抗菌药物,能显著的降低患者的医院感染发生率,降低患者的再出血的发生率及病死率,但与抗菌药物使用剂量无关.Objective To investigate the effect of different doses of antibiotics on the prevention of infection in patients with cirrhosis complicated with esophageal variceal bleeding (EVB).Methods 200 patients with liver cirrhosis complicated with EVB were selected as the research object They were randomly divided into 40 cases of A, B, C, D and E. The nosocomial infection rate, rebleeding rate and in-hospital mortality rate of the five groups were counted.Results There was no significant difference in hospital infection rate and rebleeding rate between group A and group B, group C and group D (P > 0.05),but they were lower than group E (P <0.05), while there was no significant difference in hospital mortality rate between five groups. Conclusion The prevention of antibiotics in patients with cirrhosis and upper gastrointestinal hemorrhage can significantly reduce the incidence of nosocomial infection and the incidence of re-bleeding and mortal^ but it has nothing to do with the dosage of antibiotics.

关 键 词：预防性 抗菌药物 肝硬化 食管胃底静脉曲张破裂出血 感染 

分 类 号：R451[医药卫生—治疗学]