补肾壮骨汤联合西药治疗2型糖尿病骨质疏松症(肾阳虚)随机平行对照研究  

Randomized Parallel Controlled Study of Bushen Zhuanggu Decoction Combined with Western Medicine in Treatment of Type 2 Diabetic Osteoporosis( Kidney Yang Deficiency)

作　　者：伍文耀 WU Wenyao(Yangjiang Hospital of Traditional Chinese Medicine, Yangjiang 529500 , Guangdong, China)

机构地区：[1]广东省阳江市中医医院内四科

出　　处：《实用中医内科杂志》2019年第6期13-17,共5页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察补肾壮骨汤联合西药治疗2型糖尿病骨质疏松症(肾阳虚)疗效。[方法]使用随机平行对照方法,将53例门诊患者按就诊顺序号随机分为两组。对照组26例二甲双胍,0. 5g/次,3次/d;格列吡嗪,5mg/次,2次/d;碳酸钙维D3元素片,1粒/次,1次/d,嚼服。治疗组27例补肾壮骨汤(骨碎补20g,山茱萸、丹参各15g,熟地黄20g,怀牛膝、山药各10g,杜仲15g),水煎400mL,1剂/d,早晚温服;西药治疗同对照组。连续治疗1个月为1疗程。观测临床、空腹血糖、餐后2h血糖、糖化血红蛋白、胰岛素样生长因子、血清钙、血清磷、腰椎正位的骨密度、不良反应。治疗1疗程(1个月),判定疗效。[结果]治疗组显效13例,有效11例,无效2例,总有效率92. 30%;对照组显效10例,有效9例,无效8例,总有效率70. 37%;治疗组疗效优于对照组(P <0. 05)。FPG、2hPG、Hb Alc、IGF-1两组均有改善(P <0. 01),治疗组改善优于对照组(P <0. 01)。血清钙、BMD两组均有改善(P <0. 05,P <0. 01),血清钙两组无显著差异(P> 0. 05),BMD治疗组改善优于对照组(P <0. 01),血清磷治疗组有改善(P <0. 05)对照组无显著变化(P>0. 05),治疗组改善优于对照组(P <0. 05)。[结论]补肾壮骨汤联合西药治疗2型糖尿病骨质疏松症(肾阳虚),疗效满意,无严重不良反应,值得推广。[Objective]To observe the curative effect of Bushen Zhuanggu Decoction combined with western medicine on osteoporosis of type 2 diabetes mellitus( kidney Yang deficiency).[Method]Fifty-three outpatients were randomly divided into two groups according to the order number of visits by randomized parallel control method. The control group’s 26 cases were given metformin( 0. 5 g/time,3 times/day),glipizide( 5 mg/time,2 times/day),calcium carbonate and vitamin D3 tablets( 1 tablet/time,1 time/day,chewing). In the treatment group,27 cases were treated with Bushen Zhuanggu Decoction[Gusuibu( drynaria rhizome) 20 g,Shanzhuyu( Asiatic Cornelian Cherry Fruit) 15 g,Danshen( Salvia Root) 15 g,Shudihuang( Prepared Rehmannia Root) 20 g,Huainiuxi( achyranthes bidentata) 10 g,Shanyao( Common Yam Rhizome) 10 g,Duzhong( Eucommia Bark) 15 g],400 m L for water decoction,1 dose per day for warm taking in the morning and evening. Western medicine was treated with the same as the control group. One month was a course of treatment. We observed the fasting blood sugar,postprandial 2 hours blood sugar,glycosylated hemoglobin,insulin-like growth factor,serum calcium,serum phosphorus,lumbar vertebral bone mineral density and adverse reactions. After one course of treatment( 1 month),we determined the curative effect.[Result]In the treatment group,13 cases were markedly effective,11 cases were effective,2 cases were ineffectiveand the total effective rate was 92. 30%. In the control group,10 cases were markedly effective,98 cases were effective and 8 cases were ineffective and the total effective rate was 70. 37%. The curative effect of the treatment group was better than that of the control group( P < 0. 05). FPG,2 hPG,HbAlc and IGF-1 were improved in both groups( P < 0. 01),and the improvement in treatment group was better than that in the control group( P < 0. 01). Serum calcium and BMD were improved in both groups( P < 0. 05,P< 0. 01). There was no significant difference in serum calcium between the two groups( P > 0. 05). BMD of the t

关 键 词：骨质疏松 骨痿 补肾壮骨汤 二甲双胍 格列吡嗪 空腹血糖 餐后2H血糖 糖化血红蛋白 胰岛素样生长因子 血清钙 血清磷 腰椎正位的骨密度 中药复方 随机平行对照研究 

分 类 号：R587.2[医药卫生—内分泌] R580[医药卫生—内科学]