骨科专科医院金黄色葡萄球菌临床分布及耐药性分析  

Clinical distribution and drug resistance of Staphylococcus aureus strains isolated from an orthopaedic hospital

作　　者：江琰笛[1] 陶崑[1] 朱晶晶 邬旦蓉[1] 张恩[2] JIANG Yan-di;TAO Kun;ZHU Jing-jing;WU Dan-rang;ZHANG En(Ningbo No.6 Hospital, Ningbo Zhejiang 315040;Ningbo Medical Treatment Center Li Huili Hospital,China)

机构地区：[1]宁波市第六医院,浙江宁波315040 [2]宁波市医疗中心李惠利医院

出　　处：《中国消毒学杂志》2019年第7期538-540,共3页Chinese Journal of Disinfection

基　　金：宁波市自然基金项目(2017A610280)

摘　　要：目的了解骨科专科医院金黄色葡萄球菌临床分布及耐药性,为临床合理使用抗菌药物提供依据。方法回顾性分析2012-2017年骨科专科医院住院患者分离的4 121株金黄色葡萄球菌的感染情况及耐药性。结果分离出金黄色葡萄球菌4 121株,其中耐甲氧西林金黄色葡萄球菌(MRSA) 1 055株,占25. 6%。金黄色葡萄球菌主要分离自分泌物、呼吸道、尿道和血液,分别占78. 1%、9. 2%、4. 6%和4. 2%;MRSA在ICU和骨内科的检出率较高,分别为55. 2%和24. 3%;MRSA除对万古霉素和利奈唑胺敏感100%,对呋喃妥因、喹奴普汀/达福普汀和利福平的耐药率均<25%外,对其他抗菌药物均有不同程度的耐药。结论骨科专科医院金黄色葡萄球菌特别是MRSA对多种抗菌药物产生不同程度的耐药性,应加强对MRSA耐药性的监测,指导临床合理使用抗菌药物。Objective To understand the clinical distribution and drug resistance of Staphylococcus aureus in an orthopaedic hospital so as to provide guidance for reasonable use of antibiotics. Methods A total of 4 121 strains of Staphylococcus aureus were isolated from inpatients of orthopaedic hospital from 2012 to 2017,then the incidence of infection and drug resistance were retrospectively analyzed. Results 4 121 strains of Staphylococcus aureus were isolated,of which 1 055 strains were methicillin-resistant Staphylococcus aureus( MRSA) accounting for 25. 6%. Staphylococcus aureus was mainly isolated from secretion,respiratory tract,urethra and blood,accounting for 78. 1%,9. 2%,4. 6% and 4. 2% respectively. The detection rates of MRSA in ICU and orthopedics department were relatively higher,55. 2% and 24. 3% respectively. The drug susceptibility rates of MRSA to vancomycin and linezolid were 100. 0%,the resistance rates to furantoin,quinupristin/dalfopristinand rifampicin were less than 25%,and the degrees of resistance to other antibiotics varied. Conclusion Staphylococcus aureus,especially MRSA,has different degrees of resistant to multiple commonly used antibiotics in orthopaedic hospital. It is necessary to strengthen the surveillance of MRSA resistance and guide the rational use of antibiotics in clinic.

关 键 词：骨科 金黄色葡萄球菌 临床分布 耐药性 

分 类 号：R97[医药卫生—药品]