尿激酶用法用量对高血压脑出血钻孔术后的影响  

Effect of Dosage of Urokinase on Hypertensive Intracerebral Hemorrhage after Hard-channel Trepanation and Drainage

作　　者：王东 穆苍山[1] 杨凯[1] 潘海鹏[1] 张波[1] 张毅[1] 申俊峰 金永健 WANG Dong;MU Cangshan;YANG Kai(Aviation General Hospital Neurological Center Traumatic Cerebrovascular Neurosurgery, Beijing 100012, China)

机构地区：[1]航空总医院神经中心创伤脑血管神经外科

出　　处：《航空航天医学杂志》2019年第7期782-784,共3页Journal of Aerospace medicine

摘　　要：目的探讨研究高血压脑出血钻孔引流术后,尿激酶溶解血栓的时间、用法、用量,对血肿3天清除率、1年后致残率的影响。方法筛选100例脑出血患者进行回顾性分析。治疗组50例,对照组50例。两组患者均采用硬通道钻孔引流术,术后给予尿激酶溶栓治疗。结果 3天平均血肿清除率治疗组为74. 30%,对照组56. 64%。一年后中、重度致残率,治疗组24%,对照组46%。结论硬通道钻孔引流术,术后尿激酶溶解血肿。血肿3天清除率治疗组高于对照组(常规尿激酶溶栓);1年后中、重度致残率治疗组低于对照组(常规尿激酶溶栓)。此方法优于常规尿激酶溶栓治疗,值得神经外科临床医生借鉴。Objective To investigate the efficacy on different time,usage and dosage of urokinase in patients with hypertensive intracerebral hemorrhage after minimally ivasive trepanation-drainage on 3-day hematoma evacuation rate and 1-year disability rate.Methods 100 patients with cerebral hemorrhage were screened for retrospective analysis.There were 50 patients in the treatment group and 50 patients in the control group. Both groups of patients underwent hard-channel trepanation and drainageand,and urokinase thrombolysis was given after surgery. Results The 3-day hematoma evacuation rate was 74. 30% in the treatment group and 56. 64% in the control group. After 1 year,the moderate-to-severe disability rate was 24% in the treatment group and 46% in the control group. Conclusions Hard-channel minimally ivasive trepanation-drainage,postoperative urokinase lysis hematoma. The 3-day hematoma evacuation rate of hematoma was higher in the treatment group than in the control group( conventional urokinase thrombolysis);the moderate-to-severe disability rate was lower in the treatment group than in the control group after 1 year. This method is superior to conventional urokinase thrombolytic therapy and is worthy of reference by neurosurgical clinicians.

关 键 词：尿激酶 高血压 脑出血 清除率 致残率 高血压脑出血 

分 类 号：R651.1[医药卫生—外科学]