脂肪衰减参数评估不同程度脂肪肝的临床初步研究  

Preliminary Clinical Study on Fat Attenuation Parameters For Evaluating Different Degrees of Fatty Liver

作　　者：李凤舞 孙晓慧 何琼[3] 罗建文[3] 赵强[2] 崔立刚[1] Li Fengwu;Sun Xiaohui;He Qiong;Luo Jianwen;Zhao Qiang;Cui Ligang(Ultrasound Diagnostic Department, Radiology Department, Peking University Third Hospital, Beijing 100191, China;Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China)

机构地区：[1]北京大学第三医院超声科,北京市100191 [2]北京大学第三医院放射科,北京市100191 [3]清华大学医学院生物医学工程系

出　　处：《中国超声医学杂志》2019年第8期702-705,共4页Chinese Journal of Ultrasound in Medicine

基　　金：中国博士后科学基金面上项目(No.2017M620802);国家自然科学基金青年科学基金项目(No.61801261)

摘　　要：目的探讨瞬时弹性成像系统FibroTouch脂肪衰减参数(FAP)诊断不同程度脂肪肝的意义,以及FAP的相关因素。方法随机选取就诊于我院超声诊断科患者为被检测对象,行常规超声检查进行脂肪肝程度分级(S0、S1、S2、S3分别对应无、轻度、中度、重度);同时行FibroTouch检查,测定FAP,获得不同程度脂肪肝的最佳界值。同时分析FAP与BMI、SCD、LSM相关性。结果共纳入受试者767例,其中S0 401例,S1 164例,S2 160例,S3 42例,ROC曲线分析得出,≥S1、≥S2、≥S3的FAP界值分别为243、268、285dB/m,其对应的灵敏度、特异度分别为0.87%、0.80%、0.86%、0.84%、0.76%、0.95%。FAP值与BMI、SCD、LSM均呈正相关。结论脂肪衰减参数可以定量评估肝脏脂肪化严重程度,对脂肪肝患者的随访及监测具有重要意义,并且与BMI、SCD、LSM具有相关性。Objective This article focuses on the significance of fat attenuation parameters(FAP)in diagnosing different degrees of fatty liver in transient elastography systems,named FibroTouch,and the related factors of FAP.Methods The patients were selected randomly from the Ultrasound Diagnostic Department in Peking University Third Hospital.The degree of fatty liver was graded(S0,S1,S2,and S3 correspond to none,mild,moderate,and severe respectively)by conventional ultrasound.At the same time,FibroTouch was performed to test the fat attenuation parameters.Then we analyzed the best cutoff value of different degrees,and found out the correlation between FAP and BMI,SCD and LSM.Results A total of 767 cases were included,including 401 cases of S0,164 cases of S1,160 cases of S2,and 42 cases of S3.The ROC curve analysis showed that the FAP cut-off value of≥S1,≥S2,≥S3 was243,268,285 dB/m respectively.The sensitivity and specificity were 0.87%,0.80%,0.86%,0.84%,0.76%,0.95%,respectively.The FAP value was positively correlated with BMI,SCD,and LSM.Conclusions Fat attenuation parameter can assess the degree of hepatic steatosis,which is of great significance for the follow-up and monitoring of patients with fatty liver.FAP is related to BMI,SCD,LSM.

关 键 词：脂肪性肝病 瞬时弹性成像系统FibroTouch 脂肪衰减参数 

分 类 号：R445.1[医药卫生—影像医学与核医学] R575.5[医药卫生—诊断学]