地榆水溶性化学成分研究(Ⅱ)  

Hydrosoluble chemical constituents in Sanguisorba officinalis(Ⅱ)

作　　者：王丽娜[1] 金梦莹 冯丹[1] 曹钰镁 李民主 邓赟[1] 郭大乐[1] WANG Li-na;JIN Meng-ying;FENG Dan;CAO Yu-mei;LI Min-zhu;DENG Yun;GUO Da-le(Key Laboratory of Standardization of Chinese Herbal Medicine of Ministry of Education,Breeding Base of State Key Laboratory ofScientific Research and Exploitation of Traditional Chinese Medicine Resources,School of Pharmacy,Chengdu University ofTraditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室四川省中药资源系统研究与开发利用重点实验室-省部共建国家重点实验室培育基地

出　　处：《中草药》2019年第13期3017-3023,共7页Chinese Traditional and Herbal Drugs

基　　金：国家科技部新药创制重大专项:中药大品种技术改造与技术提升研究(地榆生白片技术改造)(2014ZX09201021-008);中药药效物质基础研究与创新中药发现四川省青年科技创新研究团队(2016TD0006);四川省科技厅支撑计划项目:中药种质资源库建设关键技术研究及示范(2014SZ0156)

摘　　要：目的研究地榆Sanguisorba officinalis水溶性化学成分。方法采用大孔树脂(D101、HP-20)、透析袋、Toyopearl HW-40、反相硅胶RP18等柱色谱方法进行分离纯化,并运用1H-NMR、13C-NMR、ESI-MS等多种波谱方法对化合物进行结构鉴定。结果从地榆10%乙醇部位中分离并鉴定了25个化合物,分别为4-(4′-hydroxyphenyl)-2-butanone-4′-O-β-Dglucopyranoside(1)、phenethanol-β-vicianoside(2)、junipetrioloside A(3)、citroside A(4)、corchoionoside C(5)、adenosine(6)、tryptophan(7)、tachinoside(8)、d-mandelicacid-β-D-glucopyranoside(9)、(+)-(7S,8S)-guaiacylglycerol8-O-β-Dglucopyranoside(10)、biophenol(11)、3,5-dihydroxyphenethyl alcohol 3-O-β-glucopyranoside(12)、syringin(13)、(2E,5E)-3,7-dimethyl-2,5-octadiene-1,7-diol(14)、(±)-3-hydroxy-3,7-dimethyloct-6-enoic acid(15)、(2Z)-2,6-dimethyl-2,7-octadiene-1,6-diol(16)、phlorizin(17)、(+)-cyclo-olivil-6-O-β-D-glucopyranoside(18)、5′-methoxy-8′-hydroxyl-(+)-isolariciresinol-4′-O-β-Dglucopyranoside(19)、phenethyl-6-O-α-L-arabinofuranosyl-β-D-glucoside(20)、gaultherin(21)、benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (22)、(2E)-7-hydroxy-3,7-dimethyl-2-octenyl-6-O-α-L-arabinofuranosyl-β-D-glucopyranoside (23)、3,3′,4′-tri-O-methylellagic acid(24)、methyl-4-(β-D-glucopyranosyloxy)-3-hydroxy-5-methoxybenzoate(25)。结论化合物1~22为首次从该植物中分离得到。Objective To study the chemical constituents in extract of Sanguisorba officinalis. Methods Compounds were isolated from 10% ethanol extracts by Macroporous resin(D101, HP-20), dialysis bag, reversed phase silica gel(RP-8, RP-18), Toyopearl HW-40 column chromatography and their structures were elucidated by NMR and MS data. Results Twenty-five compounds were isolated and their structures were elucidated as 4-(4′-hydroxyphenyl)-2-butanone-4′-O-β-D-glucopyranoside(1), phenethanol-β-vicianoside(2), junipetrioloside A(3), citroside A(4), corchoionoside C(5), adenosine(6), tryptophan(7), tachinoside(8), d-mandelic acid-β-D-glucopyranoside(9),(+)(7 S,8 S)-guaiacylglycerol 8-O-β-D-glucopyranoside(10), biophenol(11), 3,5-dihydroxyphenethyl alcohol 3-O-β-glucopyranoside(12), syringin(13),(2 E,5 E)-3,7-dimethyl-2,5-octadiene-1,7-diol(14),(±)-3-hydroxy-3,7-dimethyloct-6-enoic acid(15),(2 Z)-2,6-dimethyl-2,7-octadiene-1,6-diol(16), phlorizin(17),(+)-cyclo-olivil 6-O-β-D-glucopyranoside(18),5′-methoxy-8′-hydroxyl-(+)-isolariciresinol-4′-O-β-D-gluco-pyranoside(19), phenethyl 6-O-α-L-arabinofuranosyl-β-D-glucoside(20), gaultherin(21), benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside(22),(2 E)-7-hydroxy-3,7-dimethyl-2-octenyl6-O-α-L-arabinofuranosyl-β-D-glucopyranoside(23), 3,3′,4′-tri-O-methylellagic acid(24), and methyl-4-(β-D-glucopyranosyloxy)-3-hydroxy-5-methoxybenzoate(25). Conclusion Compounds 1-22 were isolated from this plant for the first time.

关 键 词：地榆 水溶性 junipetrioloside A citroside A corchoionoside C 

分 类 号：R284.1[医药卫生—中药学]