间充质干细胞调控细胞自噬机制的研究进展  

Review of regulation mechanisms for cell autophagy induced by mesenchymal stem cell

作　　者：米向斌[1] 赖宽[2] 魏姗姗 MI Xiangbin;LAI Kuan;WEI Shanshan(Department of Dermatology,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China)

机构地区：[1]南方医科大学珠江医院皮肤科,广州510280 [2]南方医科大学南方医院皮肤科,广州510515

出　　处：《实用医学杂志》2019年第15期2495-2498,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金青年项目(编号:81803119)

摘　　要：间充质干细胞(mesenchymal stem cell,MSC)是来源于中胚层的成体干细胞,可通过激活mTOR通路、STAT3通路等途径调控宿主细胞自噬,被认为是一种有前景的免疫治疗手段。本文结合相关基础、临床研究,就间充质干细胞及其外泌体对宿主细胞自噬的作用机制做一综述。Mesenchymal stem cells are adult stem cells derived from mesoderm that can regulate host cell autophagy by activating mTOR pathway,STAT3 pathway or other pathways,and are considered to be a promising immunotherapeutic method. Here,we reviewed the regulation of mesenchymal stem cells and their exosomes on autophagy of host cells from relevant basic and clinical research.

关 键 词：间充质干细胞 外泌体 自噬 mTOR通路 STAT3通路 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]