突发性聋行声频共振联合鼓室内注射甲泼尼松龙的临床效果观察  

Clinical effect of acoustic resonance combined with methylprednisolone injection in tympanum in treating patients with sudden deafness

作　　者：刘飞 王占江 LIU Fei;WANG Zhanjiang(Department of Otorhinolaryngology,Xi'an Central Hospital,Xi'an,Shaanxi,710003)

机构地区：[1]陕西省西安市中心医院耳鼻喉科

出　　处：《实用临床医药杂志》2019年第13期85-88,共4页Journal of Clinical Medicine in Practice

摘　　要：目的 探讨突发性聋患者应用声频共振与鼓室内注射甲泼尼松龙联合治疗方案的临床疗效。方法 将88例突发性聋患者按照治疗方案的不同分为研究组和对照组,各44例。研究组患者接受声频共振联合鼓室内注射甲泼尼松龙治疗方案,对照组患者接受鼓室内注射甲泼尼松龙治疗方案。观察2组在不同疗程后的临床疗效,比较治疗前后各时间点平均听阈的变化,并观察不良反应。结果 治疗1个疗程后,观察组与对照组的痊愈率和总有效率无显著差异(P>0.05);治疗3、6个疗程后,观察组的总有效率分别为72.73%、79.55%,显著高于对照组的68.18%、70.45%(P<0.05),且治疗6个疗程后,观察组的痊愈率47.73%显著高于对照组38.64%(P<0.05)。治疗3、6个疗程后,观察组平均听阈值分别为(41.96±19.13)、(37.17±18.89)dB,显著低于对照组的(50.89±18.14)、(48.93±17.84)dB(P<0.05);治疗1个疗程后,2组间平均听阈值无显著差异(P>0.05)。结论 声频共振能激活神经毛细胞,减轻局部炎性反应,还能促进鼓室给药途径药物的渗透,并缓慢持久地维持内耳药物的有效作用,故声频共振与鼓室内注射甲泼尼松龙联合应用能进一步提高突发性聋患者的听力水平。Objective To investigate the clinical efficacy of combined therapy of acoustic resonance and injection of methylprednisolone in tympanum in treating patients with sudden deafness.Methods A total of 88 sudden deafness cases treated in our hospital were included in the study,and were divided into the control group( n = 44) and study group( n = 44) according to the different treatments. The study group received acoustic resonance combined with injection of methylprednisolone in tympanum,while the control group only received methylprednisolone injection in tympanum. The clinical efficacy of the two groups after different treatments were compared,the changes of average hearing threshold at different time points before and after treatments were analyzed,and the adverse reactions were observed. Results After one course of treatment,there was no significant difference in the rate of recovery and total efficacy between the two groups( P > 0. 05). After 3 and 6 courses of treatment,the total effective rates of the observation group were 72. 73% and 79. 55%,which were significantly higher than 68. 18%,70. 45%,respectively,in the control group( P < 0. 05). After 6 courses of treatment,the observation group had significantly higher cure rate than that of the control group( 47. 73% vs. 38. 64%,P < 0. 05). The average hearing threshold of the observation group was( 41. 96 ± 19. 13),( 37. 17 ± 18. 89) d B at 3-and 6-month treatment,which were significantly lower than( 50. 89 ± 18. 14),( 48. 93 ± 17. 84) d B,in the control group( P < 0. 05). After one course of treatment,the average threshold values of showed no between-group significant differences( P < 0. 05).Conclusion Acoustic resonance can activate the nerve hair cells,reduce the local inflammatory response,promote permeation of the tympanic drug and continuously maintain the inner ear drug efficacy. Therefore,the combined therapy can further improve the hearing level of patients with sudden deafness.

关 键 词：突发性聋 声频共振 鼓室内注射甲泼尼松龙 听阈 听力水平 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]