S100A4参与类风湿关节炎发病机制的研究进展  

Advances in research on S100A4 involved in the pathogenesis of rheumatoid arthritis

作　　者：徐武岩 查丁胜[1] 吴昊[1] 阳华 林宏生[1] 查振刚[1] XU Wuyan;ZHA Dingsheng;WU Hao;YANG Hua;LIN Hongsheng;ZHA Zhengang(Department of Orthopedics,First Affiliated Hospital of Jinan University,Guangzhou 510630,China)

机构地区：[1]暨南大学附属第一医院骨科

出　　处：《中国骨科临床与基础研究杂志》2019年第2期116-122,共7页Chinese Orthopaedic Journal of Clinical and Basic Research

基　　金：国家自然科学基金青年项目(81401766);广东省医学科研基金(B2012196);广东省科技计划项目(2017ZC0007);暨南大学科研培育与创新基金青年基金(21612303);暨南大学附属第一医院培育基金(2012-1)

摘　　要：类风湿关节炎(RA)是一种常见病、多发病,病情迁延反复,是造成我国人群劳动力丧失与致残的主要病因之一。S100钙结合蛋白A4(S100A4)是低分子量的S100家族成员之一,已被证实其过度表达与癌症进展相关,目前其在RA发病机制中的作用也受到广泛关注。相关体外研究从分子水平揭示,S100A4可通过参与调节细胞凋亡和组织重塑、刺激细胞增殖以及促进新生血管形成过程,引起RA炎症、滑膜增殖、血管翳形成和组织破坏,进而加速RA的发生发展;动物在体研究也发现S100A4水平与RA的发生发展关系密切;S100A4在预测RA患者的疾病转归、治疗效果及疾病活动度方面,亦具有独特优势。本文简要介绍S100A4的生物学功能,重点对S100A4参与RA发病机制的体外、体内和临床研究进行综述,以期为RA的早期预防、诊断、治疗及特异性药物的开发提供依据。Rheumatoid arthritis(RA)is a kind of common and frequently-occurring diseases with repeated and protracted course,which is one of the main causes of labor loss and disability in the Chinese population.As a member of S100 family with low molecular weight,S100 calcium-binding protein A4(S100A4)has been proved that its over-expression correlating to the progress of cancer,and nowadays,the roles of S100A4 in RA mechanism has attracted widespread attention.In vitro relative studies have revealed from molecular level,that S100A4 can participate in regulating cell apoptosis and tissue remodeling,stimulating cell proliferation and accelerating angiogenesis,thus leading to RA inflammation,synovial proliferation,occurrence of pannus of synovium and tissue destruction,which could promote the development of RA.In vivo animal experiment studies have also found that the level of S100A4 is closely related to the occurrence of RA.In addition,S100A4 has unique advantages in predicting the prognosis,therapeutic effect and disease activity of RA patients.This article briefly introduces the biological functions of S100A4,and reviews focusing on in vitro,in vivo and clinical studies of its involvement in the pathogenesis of RA,so as to provide evidences for the early prevention,diagnosis,treatment and development of specific drugs for RA.

关 键 词：关节炎 类风湿 S100钙结合蛋白A4 滑膜 细胞凋亡 细胞增殖 基因 p53 基质金属蛋白酶类 血管内皮生长因子类 体外研究 模型 动物 预后 复发 

分 类 号：R593.22[医药卫生—内科学] R341[医药卫生—临床医学]