胎盘来源的miRNAs在子痫前期发生发展的作用及临床价值  

The roles of placenta-derived miRNAs in the occurrence and development of preeclampsia and their clinical values

作　　者：段玉萍 姜连生[1] 李莉[1] 厉倩[1] Duan Yuping;Jiang Liansheng;Li Li;Li Qian(Department of Clinical Laboratory, Shanghai First People′s Hospital Baoshan Branch, Shanghai 200940, China)

机构地区：[1]上海市第一人民医院宝山分院医学检验科,200940

出　　处：《中华检验医学杂志》2019年第7期575-580,共6页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(81701468).

摘　　要：子痫前期(PE)是危害孕产妇和新生儿生命的严重疾病,其病理生理机制尚未完全揭示。微小RNA(miRNAs)是一类小分子单链RNA,在机体生理和病理过程中发挥重要作用。近年来有学者对孕妇胎盘组织中的miRNAs进行分类,探究了这些miRNAs在PE发病过程的作用及不同来源miRNAs在子痫前期早期预测、诊断中的价值。本文就胎盘来源的miRNAs在PE发病过程中的作用机制及诊断价值作一综述。Preeclampsia (PE) is a serious disease that threatens the health of maternal and newborn. However, the etiology and pathogenesis of PE remains elusive. Micro-RNA, a class of noncoding small single stranded RNA, plays an important role in the physiologic and pathophysiologic process of PE. In recent years, some researchers classified the placenta-derived miRNAs and investigated their roles in the occurrence of PE and their potential value in the PE early diagnosis. These findings are summarized in the review.

关 键 词：先兆子痫 胎盘 微RNAS 

分 类 号：R714.244[医药卫生—妇产科学]