甲强龙联合阿奇霉素治疗肺炎支原体感染致过敏性紫癜的效果  

Effect of methylprednisolone combined with azithromycin on treatment of allergic purpura caused by Mycoplasma pneumoniae infection

作　　者：尚莹[1] 杨成胜[1] 崔怀亮[1] 娄莹[1] 可秋萍[1] SHANG Ying;YANG Cheng-sheng;CUI Huai-liang;LOU Ying;KE Qiu-ping(Xinxiang Central Hospital,Xinxiang,Henan 453000,China)

机构地区：[1]新乡市中心医院儿科

出　　处：《中华医院感染学杂志》2019年第14期2224-2227,共4页Chinese Journal of Nosocomiology

基　　金：河南省医学科技攻关计划基金资助项目(2011020025)

摘　　要：目的探索甲强龙联合阿奇霉素治疗肺炎支原体感染致过敏性紫癜效果。方法选取2012年8月-2017年2月于医院接受治疗的124例肺炎支原体感染致过敏性紫癜患儿为研究对象,按照随机数表法将患儿分为两组,对照组62例采用阿奇霉素治疗,观察组62例在对照组治疗方法基础上加以甲强龙进行治疗。比较两组患儿的临床症状、呼吸道临床症状消失时间和过敏性紫癜消失时间、临床疗效。结果观察组临床症状发生率显著低于对照组临床症状发生率,数据具有统计学意义(P<0.05)。观察组患儿临床疗效的总有效率为93.33%显著高于对照组71.67%,数据具有统计学意义(P<0.05)。观察组患儿呼吸道临床症状消失时间(6.94±1.32)d、过敏性紫癜消失时间(4.56±1.68)d显著短于对照组呼吸道临床症状消失时间(9.24±1.28)d、过敏性紫癜消失时间(6.73±2.55)d(P<0.05)。结论甲强龙联合阿奇霉素治疗肺炎支原体感染致过敏性紫癜儿童临床症状发生率和过敏性紫癜消失时间显著低于单独阿奇霉素治疗,临床疗效显著。OBJECTIVE To explore the effect of methylprednisolone combined with azithromycin on treatment of allergic purpura caused by Mycoplasma pneumoniae infection. METHODS A total of 124 children with M.pneumoniae infection-induced allergic purpura who were treated in the hospital from Aug 2012 to Feb 2017 were recruited as the study objects and randomly divided into the control group with 62 cases and the observation group with 62 cases. The control group was treated with azithromycin, while the observation group was given methylprednisolone combined with azithromycin. The clinical symptoms, time of disappearance of clinical respiratory tract symptoms, time of disappearance of allergic purpura and clinical curative effects were observed and compared between the two groups of patients. RESULTS The incidence of clinical symptoms of the observation group was significantly lower than that of the control group( P<0.05). The total effective rate of treatment of the observation group was 93.33%, significantly higher than 71.67% of the control group(P<0.05). The time of disappearance of clinical respiratory tract symptoms of the observation group was(6.94±1.32)days, significantly shorter than(9.24±1.28)days of the control group;the time of disappearance of allergic purpura of the observation group was(4.56±1.68)days, significantly shorter than(6.73±2.55)days of the control group(P<0.05). CONCLUSION The incidence of clinical symptoms is significantly lower and the time of disappearance of allergic purpura is significantly shorter in the children who are treated with methylprednisolone combined with azithromycin than in the children who are treated with single azithromycin, and the clinical curative effect is significant.

关 键 词：激素类药物 肺炎支原体感染 过敏性紫癜 疗效 

分 类 号：R725[医药卫生—儿科]