IL-6与PCT及NEU%在慢性肾衰竭合并细菌感染患者的诊断价值  

Value of IL-6, PCT and NEU% in diagnosis of chronic renal failure patients complicated with bacterial infection

作　　者：唐欢[1] 徐琨[1] 王艳[1] 杨道荣[1] 穆霞 TANG Huan;XU Kun;WANG Yan;YANG Dao-rong;MU Xia(Affiliated Hospital of Zunyi Medical Coillege , Zunyi Guizhou 563003, China)

机构地区：[1]遵义医学院附属医院泌尿内科

出　　处：《中华医院感染学杂志》2019年第13期1967-1970,共4页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(81260118)

摘　　要：目的探讨白细胞介素-6 (IL-6)、降钙素原(PCT)及中性粒细胞百分含量(NEU%)在慢性肾衰竭合并细菌感染患者中的诊断价值。方法选取2016年4月-2018年4月于医院泌尿内科诊断为慢性肾衰竭合并细菌感染的患者,共计96例为感染组,选择同期诊断为慢性肾衰竭但未发生细菌感染的患者100例为非感染组。对比分析两组患者感染指标(IL-6、PCT、NEU%)的差异。结果慢性肾衰竭合并细菌感染的患者(感染组)血清中的感染指标(IL-6、PCT和NEU%)均高于未发生细菌感染的患者(未感染组),差异有统计学意义(P<0.05)。在感染组中,不同感染指标之间的诊断效能的差异有统计学意义(P<0.05)。从不同诊断效能的占比可以看出,PCT诊断慢性肾衰竭合并细菌感染时的灵敏度、特异度、阳性似然比、阴性似然比均优于IL-6和NEU%。PCT的ROC曲线下面积显著大于IL-6和NEU%,且差异有统计学意义(P<0.05)。结论 PCT、IL-6以及NEU%对于早期诊断慢性肾衰竭合并细菌感染有一定的价值,且PCT的临床诊断效能优于IL-6和NEU%,PCT可独立的作为辅助诊断指标,在早期发现慢性肾衰竭患者中的感染病例起着重要作用。OBJECTIVE To explore the value of interleukin-6(IL-6), procalcitonin(PCT) and percentage of neutrophils(NEU%) in diagnosis of chronic renal failure patients complicated with bacterial infection. METHODS Totally 96 patients who were diagnosed with chronic renal failure complicated with bacterial infection in department of urology from Apr 2016 to Apr 2018 were assigned as the infection group, meanwhile, 100 patients who were diagnosed with chronic renal failure but did not have bacterial infection were set as the non-infection group. The levels of infection indexes IL-6, PCT and NEU% were observed and compared between the two groups of patients. RESULTS The levels of infection indexes IL-6, PCT and NEU% of the infection group were significantly higher than those of the non-infection group(P<0.05). There was significant difference in the diagnostic efficacy among the infection indexes in the infection group(P<0.05). As compared with the diagnostic efficacy, the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of the PCT were higher than those of the IL-6 and NEU% in the diagnosis of chronic renal failure complicated with bacterial infection. The area under ROC curve of the PCT was significantly larger than that of the IL-6 and NEU%(P<0.05). CONCLUSION The PCT, IL-6 and NEU% have certain value in early diagnosis of the chronic renal failure complicated with bacterial infection, and the diagnostic efficacy of the PCT is better than that of the IL-6 and NEU%. The PCT can serve as auxiliary diagnostic index and plays an significant role in early diagnosis of infection in the patients with chronic renal failure.

关 键 词：慢性肾衰竭 细菌感染 白细胞介素-6 降钙素原 中性粒细胞百分含量 

分 类 号：R692.5[医药卫生—泌尿科学]