外周血红细胞分布宽度和支原体肺炎重症感染患儿心脏疾病的关系研究  

Relationship between red cell distribution width of peripheral blood and cadiac diseases children with severe Mycoplasma pneumonia

作　　者：李立学[1] 王涛 王平康[1] 张祥[1] 陈雅祺 LI Li-xue;WANG Tao;WANG Ping-kang;ZHANG Xiang;CHEN Ya-qi(Jianyang People's Hospital , Jianyangy Sichuan 641400, China)

机构地区：[1]简阳市人民医院儿科,四川简阳641400 [2]四川大学华西第二医院小儿心血管科,四川成都610041

出　　处：《中华医院感染学杂志》2019年第13期2033-2036,共4页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(81701888)

摘　　要：目的探索外周血红细胞分布宽度(RDW)和支原体肺炎重症感染患儿心脏疾病的相关性。方法选取2015年12月-2017年12月于医院接受治疗的118例支原体肺炎重症感染患儿为观察组,同期于医院接受体检的118名健康体检儿童为对照组。观察组按照RDW分为RDW增高组和RDW正常组,对比两组患儿心脏不良事件发生率。结果观察组RDW、血红蛋白(Hb)、白细胞计数(WBC)指标含量水平显著高于对照组,差异具有统计学意义(P<0.05)。118例支原体肺炎重症感染患儿中76例患儿RDW增高,42例患儿RDW正常,RDW增高组恶性心律失常、心力衰竭、再发心肌梗死等心脏不良事件总发生率为19.74%,明显高于RDW正常组,差异具有统计学意义(P<0.05)。118例支原体肺炎重症感染患儿中发现124株病原菌,革兰阴性菌共79株占比63.71%,革兰阳性菌共41株占比33.06%,真菌4株占比3.23%。结论支原体肺炎重症感染患儿以革兰阴性菌为主,支原体肺炎重症感染患儿RDW、Hb、WBC指标含量水平增高明显,且RDW增高与恶性心律失常、心力衰竭、再发心肌梗死等心脏疾病关系密切。OBJECTIVE To explore the relationship between red cell distribution width(RDW) of peripheral blood and cadiac diseases in children with severe Mycoplasma pneumonia. METHODS Totally 118 children with severe pneumonia who were treated in hospitals from Dec 2015 to Dec 2017 were assigned as the observation group, meanwhile, 118 healthy children who received physical examination were set as the control group. The children in the observation group were divided into the increased RDW group and the normal RDW group according to the RDW. The incidence of adverse cardiac events was observed and compared between the two groups of children. RESULTS The levels of RDW, hemoglobin(Hb) and white blood cell( WBC) of the observation group were significantly higher than those of the control group(P<0.05). Of the 118 children with severe M.pneumonia, 76 had increased RDW, and 42 had normal RDW. The total incidence of adverse cardiac events such as malignant arrhythmia, heart failure and recurrent myocardial infarction was 19.74% in the increased RDW group, significantly higher than that in the normal RDW group(P<0.05). A total of 124 strains of pathogens were isolated from the 118 children with severe M.pneumonia, 79(63.71%) of which were gram-negative bacteria, 41(33.06%) were gram-positive bacteria, and 4(3.23%) were fungi. CONCLUSION The gram-negative bacteria are dominant among the pathogens isolated from the children with severe M.pneumonia;the levels of RDW, Hb and WBC of the children with severe M.pneumonia are remarkably elevated, and the increase of RDW is closely associated with the adverse cardiac disease such as malignant arrhythmia, heart failure and recurrent myocardial infarction.

关 键 词：外周血红细胞宽度 支原体肺炎 重症感染 心脏疾病 

分 类 号：R725.6[医药卫生—儿科]