烟曲霉IgG抗体检测在慢性肺曲霉病中的意义  

Significance of IgG antibody detection of Aspergillus fumigatus in chronic pulmonary aspergillosis

作　　者：刘扬[1] 李彦芹[1] 马秀清[1] 解立新[1] Liu Yang;Li Yanqin;Ma Xiuqing;Xie Lixin(Department of Respiratory Medicine, General Hospital of the Chinese People′s Liberation Army Beijing 100853, China)

机构地区：[1]中国人民解放军总医院呼吸科,北京100853

出　　处：《国际呼吸杂志》2019年第15期1131-1134,共4页International Journal of Respiration

摘　　要：目的复检烟曲霉IgG抗体的血清水平,探讨其在慢性肺曲霉病(CPA)中的意义;分析抗真菌治疗前后抗体滴度变化,为CPA的早期诊断、治疗及连续监测提供帮助。方法选取42例疑似患者,酶联免疫吸附测定方法检测血清中烟曲霉IgG抗体水平变化;并对阳性(>120 AU/ml)以及可疑阳性(80~120 AU/ml)患者抗真菌治疗后复检,统计分析其在诊断及治疗效果评价过程中的意义。结果42例有复检结果的患者中,20例呈阳性、6例呈可疑阳性,其血清中烟曲霉IgG抗体水平显著增高;其中16例阳性及5例可疑阳性抗真菌治疗后患者临床症状明显减少,烟曲霉IgG水平整体呈显著下降趋势,其中阳性患者(>120 AU/ml)的治疗效果更加显著。结论烟曲霉IgG抗体检测对肺曲霉病的早期临床诊断具有重要意义;其血清水平的变化能够直观的反应阳性患者(>120 AU/ml)抗真菌治疗的预后。Objective To examine the serum level of Aspergillus fumigatus IgG antibody and to explore its significance in chronic pulmonary aspergillosis (CPA), and to analyze the change of antibody titer before and after antifungal therapy, and to provide help for the early diagnosis, treatment and continuous monitoring of chronic pulmonary aspergillosis. Methods 42 cases of suspected patients were selected and the serum levels of Aspergillus fumigatus IgG antibody in serum were detected by enzyme-linked immunosorbent assay (ELISA) method, and the positive (>120 AU/ml) and suspicious positive (80~120 AU/ml) patients were rechecked after antifungal treatment, and the significance of the diagnosis and treatment effect evaluation was analyzed. Results Of the 42 cases of reexamination, 20 cases were positive and 6 cases were suspected positive, and the serum level of Aspergillus fumigatus IgG antibody was significantly higher in the serum.The clinical symptoms of 16 cases and 5 cases of suspected positive antifungal treatment were significantly reduced, and the overall IgG level of Aspergillus fumigatus decreased significantly, and the positive patient (>120 AU/ml) treatment was significantly decreased.The therapeutic effect was more significant. Conclusions The detection of Aspergillus fumigatus IgG antibody is of great significance in the early diagnosis of pulmonary aspergillosis, and the changes in serum level can be intuitively reacted positive patients (>120 AU/ml) for the prognosis of antifungal therapy.

关 键 词：烟曲霉菌 免疫球蛋白G 肺曲霉菌病 酶联免疫吸附测定 抗真菌药 

分 类 号：R519[医药卫生—内科学] R446.5[医药卫生—临床医学]