Gremlin与肺动脉高压  

Gremlin and pulmonary hypertension

作　　者：张云霞 缪冉 翟振国[2] 王辰[3] Zhang Yunxia;Miao Ran;Zhai Zhenguo;Wang Chen(Department of Respiratory Disease, Capital Medical University, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing 100020, China;Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Disease, Beijing 100029, China;Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100029, China)

机构地区：[1]首都医科大学呼吸病学系北京市呼吸和肺循环重点实验室,100020 [2]国家呼吸病学临床研究中心中日友好医院呼吸与危重症医学科,北京100029 [3]中国医学科学院,北京协和医学院,100029

出　　处：《国际呼吸杂志》2019年第15期1190-1193,共4页International Journal of Respiration

基　　金：国家重点研发计划(2016YFC0905600);国家自然科学基金项目(81570049、81300044);北京市自然科学基金项目(7152062、7162069).

摘　　要：肺动脉高压(PH)是一种由异源性疾病和不同发病机制引起的以肺动脉压力增高为主要表现的疾病状态,严重者出现右心衰竭,预后差。Gremlin是一种细胞外糖蛋白,作为骨形态形成蛋白(BMP)的拮抗剂,在胚胎气道和肺循环发育中发挥了关键作用。本文综合分析Gremlin在PH发生发展中的作用,发现Gremlin通过抑制肺动脉内皮细胞损伤修复、促进平滑肌细胞增殖、迁移,诱导细胞外基质沉积及炎症细胞浸润,参与PH的发生发展过程,成为PH治疗的新的靶点。Pulmonary hypertension (PH) is characterized by sustained increase of pulmonary arterial pressure and eventually leading to right heart failure.PH is caused by heterogeneous diseases and different pathogenesis.Gremlin is an extracellular glycoprotein that was first identified over a decade ago through its important role in embryonic development, in which it acts as an antagonist of bone morphogenetic protein actions.It plays a critical role in the development of normal airways and the pulmonary circulation in the embryo.The article reviews that Gremlin contributes to the pathogenesis of pulmonary hypertension by inhibiting the repair of pulmonary artery endothelial cells, promoting smooth muscle cell proliferation and migration, inducing extracellular matrix deposition and infiltration of inflammatory cells which suggests future avenues of research.

关 键 词：肺动脉高压 GREMLIN 

分 类 号：R544.1[医药卫生—心血管疾病]