乳疾康纳米乳剂喷雾的主要药效学研究  

Pharmacodynamics Study on the spray of Ru Kang Kang nano emulsion

作　　者：李艳秋 梁雪琪 王丽江 Li Yan-qiu;Liang Xue-qi;Wang Li-jiang(Research Institute of Molecular State,Guangdong Molecular State Biology Co.,Ltd. GuangdongShenzhen 518000,China;College of Life Sciences,Zhejiang University of Traditional Chinese Medicine,Zhejiang Hangzhou 310000,China;Beijing Lipson Biotechnology Co.Ltd.,Beijing 100071,China)

机构地区：[1]广东分子态生物股份有限公司分子态研究院,广东深圳518000 [2]浙江中医药大学生命科学学院,浙江杭州310000 [3]北京利普松生物科技有限公司,北京100071

出　　处：《实用妇科内分泌电子杂志》2019年第16期1-2,共2页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的研究外用中药制剂对小鼠乳腺增生的治疗作用并探讨其机制。方法采用苯甲酸雌激素腹腔注射构建乳腺增生小鼠模型,分组为对照组、模型组与治疗组。对照组小鼠腹腔注射生理盐水,隔天1次,共30天;模型组与治疗组腹腔注射苯甲酸雌激素,隔天1次,共30天。造模完成后,治疗组小鼠乳房部涂抹外用中药制剂,每天2次共30天。测定各组小鼠体重变化,乳晕及乳头直径变化,孕酮(P)、血清雌激素(E2)指标。结果治疗组与模型组小鼠比较,体重、乳晕及乳头直径均有统计学差异(P<0.05);雌、孕激素水平较对照组无统计学差异(P>0.05),而与模型组对比则具有统计学差异(P<0.05)。结论外用中药制剂对小鼠乳腺增生具有改善作用,其机制可能是通过调节小鼠血清雌激素与孕酮水平来实现的。Objective To study and the effect of traditional Chinese medicine on the mammary gland hyperplasia in mice and to explore its mechanism.Methods The model group was established by injecting estradiol benzoate into the abdominal cavity.The mice were divided into 3 groups(control,model and therapy).Normal saline was injected into the peritoneal cavity of the control group,every 2 days,altogether 15 times in 30 days.Estradiol benzoate was injected into the peritoneal cavity of the model group and therapy group,every 2 days,altogether15 times in 30 days.After 30 days,the traditional Chinese medicine was smeared on the mammary of therapy group,once a day for 30 days.To observe the body weight changes of mice,areola and nipple diameter,serum estradiol(E2)and progesterone(P)index.Results We found the body weight and diameter of nipple of mice had differences between therapy group and model group(P<0.05).The level of estrogen and progesterone compared between the therapy group and control group showed no significant difference(P>0.05),and compared with the model group there had statistical difference(P<0.05).Conclusion The improvement effect of traditional Chinese medicine preparation for mammary gland hyperplasia in mice may be realized through regulating the mouse serum estrogen and progesterone level.

关 键 词：乳腺增生 中药外用 小鼠 

分 类 号：R97[医药卫生—药品]