初诊2型糖尿病发病年龄与代谢综合征关系研究  

Relationship between the Age of Onset of Newly Diagnosed Type 2 Diabetes and Metabolic Syndrome

作　　者：刘林杰 李慧琼[1,2] 徐焱成 LIU Linjie;LI Huiqiong;XU Yancheng(Department of Endocrinology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Department of Endocrinology,the Third Clinical Medical College of Three Gorges University/Gezhouba Central Hospital,Yichang 443001,China)

机构地区：[1]武汉大学中南医院内分泌科,湖北省武汉市430071 [2]三峡大学第三临床医学院(葛洲坝中心医院)内分泌科,湖北省宜昌市443001

出　　处：《中国全科医学》2019年第22期2688-2691,2704,共5页Chinese General Practice

基　　金：国家自然科学基金资助项目(30871188)

摘　　要：背景糖尿病是代谢综合征(MS)的重要组成成分,常合并MS其他代谢组分。目前,我国年轻糖尿病患者和老年糖尿病患者数量均逐年增多,但尚缺乏关于糖尿病发病年龄与MS及其组分的关系研究。目的探讨初诊2型糖尿病(T2DM)发病年龄与MS及MS其他代谢组分的关系。方法选取2012年1月-2017年5月在武汉大学中南医院内分泌科住院的初诊T2DM患者431例,按照发病年龄分为早发型糖尿病组(EDM,<40周岁,n=72)、中年糖尿病组(MDM,40~59周岁,n=232)、老年糖尿病组(ODM,≥60周岁,n=127),比较三组患者合并MS及MS其他代谢组分情况。结果 T2DM患者合并MS的比例为72.4%(312/431),EDM、MDM、ODM组合并MS的比例分别为79.2%(57/72)、74.1%(172/232)、65.4%(83/127),随着发病年龄的增加,初诊T2DM患者合并MS的比例降低(P<0.05)。发病年龄越早,初诊T2DM患者合并超重/肥胖、高三酰甘油(TG)血症、低高密度脂蛋白胆固醇(HDL-C)血症的比例越高,合并高血压的比例越低(P<0.05)。三组合并MS其他代谢组分的项数比较有统计学差异(P<0.05),其中,EDM与ODM组比较有统计学差异(P<0.016 7),EDM与MDM组、MDM与ODM组比较无统计学差异(P>0.016 7)。结论 T2DM患者的发病年龄与MS关系密切,发病年龄越早者合并MS的风险越高。Background Diabetes is an important component of the metabolic syndrome(MS),which often combines with other metabolic components of MS.China’s young and elderly diabetic patients are increasing year by year,but there is still a lack of studies on relationship of the age of onset of diabetes with MS and its components.Objective To investigate the relationship of the age of onset of newly diagnosed type 2 diabetes(T2DM) with MS and other metabolic components of MS.Methods 431 patients with newly diagnosed T2DM were selected from Department of Endocrinology,Zhongnan Hospital of Wuhan University from January 2012 to May 2017.According to the age of onset,they were divided into early-onset diabetes group(EDM group,<40 years,n=72),middle-aged diabetes group(MDM group,40-59 years,n=232) and elderly diabetes group(ODM group,≥ 60 years,n=127).The metabolic components of MS and MS in three groups were compared.Results The prevalence rates of MS in all the newly diagnosed T2DM cases,EDM group,MDM group,and ODM group were72.4%(312/431),79.2%(57/72),74.1%(172/232),and 65.4%(83/127),respectively.With the increase of onset age,the prevalence rate of MS in newly diagnosed patients with T2DM decreased(P<0.05).Early onset age was associated with higher prevalence rates of overweight/obesity,elevated TG,decreased HDL-C and lower prevalence rate of hypertension(P<0.05).There were statistical differences between the three groups(P<0.05).The difference was between EDM and ODM(P<0.016 7), but there was no difference between EDM and MDM,MDM and ODM(P>0.016 7).Conclusion The age of onset of newly diagnosed T2 DM was closely related to MS,and the earlier the age of onset,the higher the risk of MS.

关 键 词：糖尿病 2型 代谢综合征X 发病年龄 超重 肥胖症 高血压 高甘油三酯血症 低高密度脂蛋白胆固醇血症 

分 类 号：R587.1[医药卫生—内分泌] R589[医药卫生—内科学]