美沙酮维持治疗者使用苯丙胺类物质现状及其对治疗依从性影响的研究  

Amphetamine use and its impact on treatment compliance in methadone maintenance treatment clinics

作　　者：程曌 陈国红[2] 戴明妹 罗巍[1] 吕繁[1] 曹晓斌[1] CHENG Zhao;CHEN Guohong;DAI Mingmei;LUO Wei;LYU Fan;CAO Xiaobin(National Center for AIDS/STD Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Department of AIDS/STD Prevention and Control,Jiangsu Provincial Center for Diseases Control and Prevention,Nanjing 210009)

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,北京102206 [2]江苏省疾病预防控制中心性病艾滋病防制所,南京210009

出　　处：《中国艾滋病性病》2019年第7期709-712,共4页Chinese Journal of Aids & STD

基　　金：社区美沙酮维持治疗关怀项目(5R01DA033130-03)~~

摘　　要：目的探讨美沙酮维持治疗(MMT)者苯丙胺类物质使用现状及其对治疗依从性的可能影响。方法采用横断面调查方法,利用问卷及尿检收集MMT门诊治疗者治疗情况、家庭及社会支持情况、治疗期间毒品使用情况等信息,采用非条件Logistic回归模型等方法进行数据分析。结果纳入的496名研究对象中苯丙胺类物质使用率为9.5%(47名),其中51.1%(24/47)的人使用苯丙胺类物质≥3年,46.8%(22/47)的人使用频率<1次/周;烫吸的占53.2%,口服占31.9%。Logistic回归分析结果显示:在调整相应混杂因素后,使用苯丙胺类物质的MMT者中治疗不依从的比例更大[比值比(OR)=2.36, 95%可信区间(CI):1.16~4.81];近3年开始使用苯丙胺类物质的治疗人员更易发生治疗不依从现象(OR=4.91, 95%CI:1.22~19.73);甲基苯丙胺使用频率可能与MMT依从性无关。结论 MMT人员中使用苯丙胺类物质行为与MMT不依从有关,不同使用时长与治疗依从性之间的关联不同。Objective To explore the status of amphetamine use and its impact on treatment compliance among methadone maintenance treatment(MMT) patients. Methods A cross-sectional survey was conducted. Information about demographic characters, status of MMT and drug use, family and social support of MMT clients were collected by a well-developed questionnaire and urine test. Logistic regression models were used for the statistical analysis. Results 496 clients in MMT were recruited. 9.5%(47/496)of the clients used amphetamine, of which 51.1%(24/47) used it for more than 3 years, and 46.8%(22/47)used it less than 1 time per week. Results of logistic regression analysis indicated that after adjustment for potential confounding factors, the clients who used amphetamine had poor treatment compliance(OR=2.36, 95%CI: 1.16-4.81). Those who used amphetamine within the latest 3 years were more likely to have poor compliance(OR=4.91, 95%CI: 1.22-19.73). And the abusing frequency might not associate with MMT compliance. Conclusion Amphetamine use is prevalent among MMT clients, which is associated with poor treatment compliance. And the association may vary from different use duration.

关 键 词：美沙酮维持治疗 苯丙胺类物质 治疗依从性 

分 类 号：R163[医药卫生—公共卫生与预防医学]